Secoisolariciresinol diglucoside - 10mM in Water , CAS No.257930-74-8

CAS: 257930-74-8 Cat. No.: S654841 Molecular Weight: 686.70 PubChem CID: 72189390

GRADE & PURITY 10mM in Water

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects.

In Vitro

Secoisolariciresinol diglucoside (1-500 μM) possesses strong reducing power and high free radical scavenging activity for hydroxyl, peroxyl and DPPH free radicals. Secoisolariciresinol diglucoside (1-50 μM; 24 h) attenuates human monocyte adhesion to and migration across human brain endothelial monolayers. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Secoisolariciresinol diglucoside (4 mg/mouse; a single p.o.) diminishes leukocyte adhesion and migration across blood-brain barrier (BBB) in neuroinflammation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Hand feeding mice (10 weeks old, male) are injected with TNFαDosage: 4 mg/mouse Administration: P.o. 2 h before i.c. administration of TNFα Result: Attenuated adhesion of leukocytes to the endothelium by 50% and attenuated migration of leukocytes across the BBB by 64%.

Specifications

Specifications & Purity

10mM in Water

Biochemical and Physiological Mechanisms

Secoisolariciresinol diglucoside ((S, S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects [1

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: COC1=C(C=CC(=C1)C[C@H](CO[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)[C@H](CC3=CC(=C(C=C3)O)OC)CO[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O
• PubChem CID: 72189390
• Molecular Weight: 686.70