Sofiniclin - 10mM in DMSO , Neuronal acetylcholine receptor; alpha4/beta2 agonist, CAS No.799279-80-4, Neuronal acetylcholine receptor; alpha4/beta2 agonist

CAS: 799279-80-4 Cat. No.: S655728 Molecular Weight: 244.12 PubChem CID: 10131048

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Sofiniclin (ABT 894), an agonist of nicotinic acetylcholine receptor (nAChR) , is used as a potential non-stimulant research for attention-deficit/hyperactivity disorder (ADHD).

In Vitro

Sofiniclin is more potent than ABT-089 at both receptor subtypes, with K i values of 1.9 nM for 125 I-α-conotoxinMII binding and of 1.3 nM for 125 I-epibatidine binding. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sofiniclin (0.001 to 0.10 mg/kg, p.o.) produces significant reductions in LIDs compared to vehicle monkey . Sofiniclin (0.1 mg/kg) does not decrease LIDs in monkeys with severe nigrostriatal damage. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Sofiniclin (ABT 894), an agonist of nicotinic acetylcholine receptor (nAChR) , is used as a potential non-stimulant research for attention-deficit/hyperactivity disorder (ADHD).

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Mechanism of action

Neuronal acetylcholine receptor; alpha4/beta2 agonist

Product Properties

• ALogP: 2

Names and Identifiers

• Isomeric SMILES: C1[C@H]2CN(C[C@H]2N1)C3=CC(=C(N=C3)Cl)Cl
• PubChem CID: 10131048
• Molecular Weight: 244.12