SOP1812 - 10mM in DMSO , CAS No.2546091-70-5

CAS: 2546091-70-5 Cat. No.: S656421 Molecular Weight: 791.98 PubChem CID: 155318440

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

SOP1812 (QN-302) is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s) , and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with K D values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer.

In Vitro

SOP1812 (0-50 nM; 96 h) inhibits the proliferation of many cancer cells. SOP1812 (0-800 nM; 6-24 h) shows great affinity to hTERT G4 and HuTel21 G4. SOP1812 (40 nM; 6-24 h) affects Wnt/β-catenin, axon guidance, Hippo, MAPK and Rap1 pathways. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cell lines Concentration: 0-50 nM Incubation Time: 96 hours Result: Showed anti-proliferation ability to MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cells with GI 50 values of 1.3, 1.4, 5.9 and 2.6 nM, respectively. Cell Viability AssayCell Line: PANC-1 cells Concentration: 0, 100, 400 and 800 nM Incubation Time: 6 and 24 hours Result: Binded to hTERT G4 and HuTel21 G4 with K D values of 4.9 and 28.4 nM, respectively. Cell Viability AssayCell Line: MIA PaCa-2 Cells Concentration: 40 nM Incubation Time: 6 and 24 hours Result: Affected WNT5B, DVL1, AXIN and APC2 expression which includes in Wnt/β-catenin pathway and also showed effects on axon guidance, Hippo, MAPK, and Rap1 pathways.

In Vivo

SOP1812 (1 mg/kg; i.v. once or twice per week for 28 days) shows anti-tumor activity in MIA PaCa-2 xenografts mice and KPC mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female athymic nude mice with MIA PaCa-2 xenografts Dosage: 1 mg/kg Administration: Intravenous injection; 1 mg/kg once or twice per week; for 28 days Result: Showed complete tumor regression and no significant tumor regrowth after day 28 on several animals. Animal Model: KPC mice with PDAC symptoms Dosage: 1 mg/kg Administration: Intravenous injection; 1 mg/kg once per week; for 3 weeks Result: Significantly extended survival of KPC mice and showed a better effect than gemcitabine.

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

SOP1812 (QN-302) is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s) , and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with K D values o

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C1CCN(C1)CCN=C2C=C3C4=C(C(=CC5=C(N(C(=O)C2=C54)CCCN6CCOCC6)O)C7=CC=C(C=C7)CN8CCCC8)C(=O)N(C3=O)CCCN9CCOCC9
• PubChem CID: 155318440
• Molecular Weight: 791.98