Sotorasib (AMG510) - 10mM in DMSO , CAS No.2296729-00-3

CAS: 2296729-00-3 Cat. No.: S409151 Molecular Weight: 560.59 PubChem CID: 137278711

GRADE & PURITY 10mM in DMSO

Synonyms

Pyrido[2,​3-​d]​pyrimidin-​2(1H)​-​one, 6-​fluoro-​7-​(2-​fluoro-​6-​hydroxyphenyl)​-​1-​[4-​methyl-​2-​(1-​methylethyl)​-​3-​pyridinyl]​-​4-​[(2S)​-​2-​methyl-​4-​(1-​oxo-​2-​propen-​1-​yl)​-​1-​piperazinyl]​-​, (1R)​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Sotorasib (AMG510) Sotorasib (AMG510) is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity. This AMG510 is a chiral compound.
In vitro

AMG 510 inhibits SOS1-catalyzed nucleotide exchange of recombinant mutant KRAS (G12C/C118A) but had minimal effect on KRAS (C118A). AMG 510 also selectively impairs the viability of KRAS p.G12C mutant lines but does not affect cell lines with other KRAS mutations.

In vivo

In preclinical tumor models, AMG 510 rapidly and irreversibly binds to KRAS (G12C), providing durable suppression of the mitogen-activated protein kinase (MAPK) signaling pathway. Dosed orally (once daily) as a single agent, AMG 510 is capable of inducing tumor regression in mouse models of KRASG12C cancer.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyms

Pyrido[2, ​3-​d]​pyrimidin-​2(1H)​-​one, 6-​fluoro-​7-​(2-​fluoro-​6-​hydroxyphenyl)​-​1-​[4-​methyl-​2-​(1-​methylethyl)​-​3-​pyridinyl]​-​4-​[(2S)​-​2-​methyl-​4-​(1-​oxo-​2-​propen-​1-​yl)​-​1-​piperazinyl]​-​, (1R)​-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Sotorasib (AMG510) is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.This AMG510 is a chiral compound.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C[C@H]1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C
• PubChem CID: 137278711
• Molecular Weight: 560.59

Associated Targets(Human)

KRAS Tclin GTPase KRas (2 Activities)

Discover Target: KRAS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

References

1. Junsong Qin, Zhepeng Chen, Chuangyan Wang, Lin Mai, Xian Wang, Junfeng Li, Hui Liu, Yun Song.  (2025)  Interaction Mechanisms of KRAS G12C Inhibitors (Sotorasib and Adagrasib) with Human Serum Albumin: Insights from Spectroscopic and Molecular Docking Studies.  MOLECULES,  30  (16): (3436).  [PMID:40871588] [10.3390/molecules30163436]

2. Yang Chen, Wenzhe Xu, Hao Jin, Mengsi Zhang, Shuwei Liu, Yi Liu, Hao Zhang.  (2024)  Nutritional Glutamine-Modified Iron-Delivery System with Enhanced Endocytosis for Ferroptosis Therapy of Pancreatic Tumors.  ACS Nano,      [PMID:39512234] [10.1021/acsnano.4c08083]