Spadin TFA - ≥99% , CAS No.S659299

CAS: S659299 Cat. No.: S659299 Formula: C₉₂H₁₄₃F₃N₂₆O₂₄ Molecular Weight: 2126.36

GRADE & PURITY ≥99%

Storage

Protected from light,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC 50 value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and

Appearance:Solid

In Vitro:Spadin TFA (100 nM; COS-7 cells) has inhibitory effect of spadin on the TREK-1 channel and blocks 63% of the TREK-1 current stimulated by arachidonic acid. Spadin TFA (100 nM) blocks the TREK-1 channels activity in CA3 hippocampal neurons on brain sl

In Vivo:Spadin TFA (10 μM, 100 μL; i.p.; for 30 min; male C57Bl/6J and TREK-1 deficient mice) increases of the 5-HT neuron firing rate in the dorsal raphe nucleus (DRN). Spadin TFA (0.01-100 μM, 100 μL; ICV, i.p. and i.v.; daily, for 7 days; male C57Bl/6J an

Biological Activity:Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC 50 value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and

Specifications

Specifications & Purity

≥99%

Storage

Protected from light,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

Molecular Weight

2126.36

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (47.03 mM; Need ultrasonic) H2O : 25 mg/mL (11.76 mM; Need ultrasonic)