Strychnine hydrochloride - Moligand™, ≥99% , CAS No.1421-86-9

CAS: 1421-86-9 Cat. No.: S275288 Molecular Weight: 370.87 EC Number: 215-826-9 PubChem CID: 16219987

GRADE & PURITY Moligand™, ≥99%

Synonyms

Strychnidin-10-one, monohydrochloride | Strychnine Hydrochloride Hydrate | CHEBI:90699 | STRYCHNINE HYDROCHLORIDE [WHO-DD] | CCG-208325 | Strychnine, monohydrochloride | D92242 | SCHEMBL184168 | Strychnine hydrochloride | STRYCHNINE HYDROCHLORIDE, (-)- |

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Product Application：
Strychnine Hydrochloride acts as an antagonist for cholinesterases and beta amyloid aggregation.

Specifications

Synonyms

Strychnidin-10-one, monohydrochloride | Strychnine Hydrochloride Hydrate | CHEBI:90699 | STRYCHNINE HYDROCHLORIDE [WHO-DD] | CCG-208325 | Strychnine, monohydrochloride | D92242 | SCHEMBL184168 | Strychnine hydrochloride | STRYCHNINE HYDROCHLORIDE, (-)- |

Specifications & Purity

Moligand™, ≥99%

Biochemical and Physiological Mechanisms

Competitive glycine receptor antagonist. Convulsant. Also antagonist at α7 receptors and α4β2 nicotinic receptors.

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: C1CN2CC3=CCOC4CC(=O)N5C6C4C3CC2C61C7=CC=CC=C75.Cl
• IUPAC Name: (4aR,5aS,8aR,13aS,15aS,15bR)-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one;hydrochloride
• InChIKey: VLXYTKMPCOQKEM-ZEYGOCRCSA-N
• INCHI: 1S/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19-,20-,21+;/m0./s1
• Isomeric SMILES: C1CN2CC3=CCO[C@H]4CC(=O)N5[C@H]6[C@H]4[C@H]3C[C@H]2[C@@]61C7=CC=CC=C75.Cl
• PubChem CID: 16219987
• Molecular Weight: 370.87

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Alkaloids and derivatives
    • Class Strychnos alkaloids

• Kingdom: Organic compounds
• Superclass: Alkaloids and derivatives
• Class: Strychnos alkaloids
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Strychnos alkaloids
• Alternative Parents: Carbazoles Quinolidines Indolizidines Piperidinones Aralkylamines Delta lactams N-alkylpyrrolidines Benzenoids Tertiary carboxylic acid amides Trialkylamines Amino acids and derivatives Oxacyclic compounds Azacyclic compounds Dialkyl ethers Carbonyl compounds Hydrocarbon derivatives Hydrochlorides Organic oxides Organopnictogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Strychnan skeleton - Akuammicine-skeleton - Stemmadenine-skeleton - Carbazole - Quinolidine - Indole or derivatives - Indolizidine - Delta-lactam - Piperidinone - Aralkylamine - Benzenoid - N-alkylpyrrolidine - Piperidine - Tertiary carboxylic acid amide - Pyrrolidine - Lactam - Tertiary aliphatic amine - Tertiary amine - Amino acid or derivatives - Carboxamide group - Carboxylic acid derivative - Dialkyl ether - Ether - Oxacycle - Azacycle - Organoheterocyclic compound - Hydrocarbon derivative - Organic nitrogen compound - Organic oxide - Amine - Organic oxygen compound - Carbonyl group - Organonitrogen compound - Organooxygen compound - Hydrochloride - Organopnictogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as strychnos alkaloids. These are alkaloids having a core structure based on the strychnan, stemmadenine (seco-curan), or the akuammicine (curan) skeleton.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• Sensitivity: Moisture sensitive
• Melt Point(°C): >235°C
• Molecular Weight: 370.900 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 370.145 Da
• Monoisotopic Mass: 370.145 Da
• Topological Polar Surface Area: 32.800 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 689.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 6
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Wu Jun, Zhao Miao, Jin Yu-chen, Li Min, Yu Ke-xin, Yu Hai-bo.  (2023)  Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors, alleviates seizures in multiple mouse models.  ACTA PHARMACOLOGICA SINICA,      [PMID:38017298] [10.1038/s41401-023-01195-3]

2. Yan Zhang, Xin-yue Zhao, Meng-ting Liu, Zhu-chen Zhou, Hui-bin Cheng, Xu-hong Jiang, Yan-rong Zheng, Zhong Chen.  (2025)  Strychni Semen and its active compounds promote axon regeneration following peripheral nerve injury by suppressing myeloperoxidase in the dorsal root ganglia.  Journal of Integrative Medicine-JIM,      [PMID:40069034] [10.1016/j.joim.2025.03.001]