Succinimidyl acid PEG, mPEG-NHS - MW 20000 Da

Cat. No.: S164317

GRADE & PURITY MW 20000 Da

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

N-hydroxylsuccinimide (NHS) functionalized polyethylene glycol (PEG-NHS) is an amino (-NH2) reactive PEG derivative that can be used to modify protein, peptide or any other surfaces with their available amino groups. NHS esters react with primary amine groups at pH 7~8.5 to form stable amide bonds.Compared to other PEG NHS ester derivatives, our succinimidyl carbonate (SC) functionalized mPEG-NHS offers superior reactivity and higher stability in aqueous solution. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to basic pH values to proceed. Primary amines react with NHS esters by nucleophilic attack and NHS is released as a byproduct. Hydrolysis of the NHS-ester competes with the reaction in aqueous solution and increases with increasing pH.

Specifications

Specifications & Purity

MW 20000 Da

Biochemical and Physiological Mechanisms

In general, a molar excess of 10 to 50 times the amount of amine containing material in NHS PEG is sufficient for sufficient conjugation. Required materials Connection buffer: 100 mM sodium bicarbonate buffer with pH 8.5 or other amine free buffer with pH

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Chemical and Physical Properties

• Solubility: Off-white/white solid or viscous liquid depends on molecule weight;Soluble in regular aqeous solution as well as most organic solvents
• Sensitivity: Light and moisture sensitive