Tafamidis meglumine - 10mM in DMSO , Transthyretin stabiliser, CAS No.951395-08-7, Transthyretin stabiliser

CAS: 951395-08-7 Cat. No.: T656821 Molecular Weight: 503.33 EC Number: 813-716-0

GRADE & PURITY 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC 50 s of 2.7-3.2 μM. Tafamidis meglumine inhibits amyloidogenesis

In Vitro

Tafamidis binds selectively and with negative cooperativity (K d s ∼2 nM and ∼200 nM) to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR. Tafamidis (0-7.2 μM) dose-dependently inhibits WT-TTR amyloidogenesis after treatment for 72 hours at a pH of 4.4-4.5. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:EC50: 2.7-3.2 μM (TTR)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC 50 s of 2.7-3.2 μM. Tafamidis meglumine inhibits

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

STABILISER

Mechanism of action

Transthyretin stabiliser

Names and Identifiers

• Isomeric SMILES: CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.C1=CC2=C(C=C1C(=O)O)OC(=N2)C3=CC(=CC(=C3)Cl)Cl
• Alternate CAS: 594839-88-0;90191-92-7
• MeSH Entry Terms: FX 1006A;FX-1006A;FX1006A;tafamidis;tafamidis meglumine;Vyndamax;Vyndaqel
• Molecular Weight: 503.33