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POLA1

DescriptionDNA polymerase alpha catalytic subunit

Gene and Protein Information

Gene ID5422
Uniprot Accession IDs P09884 Q86UQ7
Ensembl ID ENSP00000368349
Symbol POLA NSX POLA p180
FamilyBelongs to the DNA polymerase type-B family.
Sequence
MAPVHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDKRNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMILKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEEEQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSFLPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTNTSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEENDALLGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPLTFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQFLSRSGYSEVNLSKLFAGCAVKS
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp100611187POLA1DNA polymerase alpha 1, catalytic subunit9598VGNC:8330OMA, EggNOG
Macaque699763POLA1DNA polymerase alpha 1, catalytic subunit9544Inparanoid, OMA, EggNOG
Mouse18968Pola1polymerase (DNA directed), alpha 110090MGI:99660Inparanoid, OMA, EggNOG
Rat85241Pola1DNA polymerase alpha 1, catalytic subunit10116RGD:621816Inparanoid, OMA, EggNOG
Dog480869POLA1DNA polymerase alpha 1, catalytic subunit9615VGNC:44771Inparanoid, OMA, EggNOG
Horse100052225POLA1DNA polymerase alpha 1, catalytic subunit9796VGNC:21649Inparanoid, OMA, EggNOG
Cow534848POLA1DNA polymerase alpha 1, catalytic subunit9913VGNC:33110Inparanoid, OMA, EggNOG
Opossum100011328POLA1DNA polymerase alpha 1, catalytic subunit13616Inparanoid, OMA, EggNOG
Chicken418593POLA1DNA polymerase alpha 1, catalytic subunit9031CGNC:12201Inparanoid, OMA, EggNOG
Anole lizard100553905pola1DNA polymerase alpha 1, catalytic subunit28377Inparanoid, OMA, EggNOG
Xenopus100379926pola1polymerase (DNA directed), alpha 1, catalytic subunit8364XB-GENE-1000548Inparanoid, OMA, EggNOG
Zebrafish317740pola1polymerase (DNA directed), alpha 17955ZDB-GENE-030114-9Inparanoid, OMA, EggNOG
C. elegans176544pola-1DNA polymerase6239OMA, EggNOG
Fruitfly42553DNApol-alpha180DNA polymerase alpha 180kD7227FBgn0259113Inparanoid, OMA, EggNOG
S.cerevisiae855621POL1DNA-directed DNA polymerase alpha catalytic subunit POL14932S000005046Inparanoid, OMA, EggNOG

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      🔙[Back to Target (Human)]
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