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MAP3K5

DescriptionMitogen-activated protein kinase kinase kinase 5

Gene and Protein Information

Gene ID4217
Uniprot Accession IDs Q99683 A6NIA0 B4DGB2 Q5THN3 Q99461
Ensembl ID ENSP00000351908
Symbol ASK1 MAPKKK5 MEKK5 ASK1 MEKK5 MAPKKK5
FamilyBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Sequence
MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESAAAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp463023MAP3K5mitogen-activated protein kinase kinase kinase 59598VGNC:10797OMA, EggNOG
Macaque711382MAP3K5mitogen-activated protein kinase kinase kinase 59544Inparanoid, OMA, EggNOG
Mouse26408Map3k5mitogen-activated protein kinase kinase kinase 510090MGI:1346876Inparanoid, OMA, EggNOG
Rat365057Map3k5mitogen-activated protein kinase kinase kinase 510116RGD:1306565Inparanoid, OMA, EggNOG
Dog476215MAP3K5mitogen-activated protein kinase kinase kinase 59615VGNC:42975Inparanoid, OMA
Horse100073186MAP3K5mitogen-activated protein kinase kinase kinase 59796VGNC:19939Inparanoid, OMA, EggNOG
Cow537380MAP3K5mitogen-activated protein kinase kinase kinase 59913VGNC:31198Inparanoid, OMA
Opossum100031527MAP3K5mitogen-activated protein kinase kinase kinase 513616OMA, EggNOG
Platypus100081079MAP3K5mitogen-activated protein kinase kinase kinase 59258Inparanoid, OMA, EggNOG
Chicken421688MAP3K5mitogen-activated protein kinase kinase kinase 59031CGNC:10395OMA, EggNOG
Anole lizard100551616map3k5mitogen-activated protein kinase kinase kinase 528377Inparanoid, OMA
Zebrafish555703map3k5mitogen-activated protein kinase kinase kinase 57955ZDB-GENE-030827-3Inparanoid, OMA, EggNOG

Protein Classes

DTO Classes
protein    /    Kinase    /    Protein kinase    /    STE group    /    STE11 family    /    Mitogen-activated protein kinase kinase kinase 5

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      🔙[Back to Target (Human)]
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