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MTHFR

DescriptionMethylenetetrahydrofolate reductase

Gene and Protein Information

Gene ID4524
Uniprot Accession IDs P42898 B2R7A6 Q5SNW6 Q5SNW9 Q7Z6M6 Q8IU73 Q9UQR2
Ensembl ID ENSP00000365777
FamilyBelongs to the methylenetetrahydrofolate reductase family.
Sequence
MVNEARGNSSLNPCLEGSASSGSESSKDSSRCSTPGLDPERHERLREKMRRRLESGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAGDPGSDKETSSMMIASTAVNYCGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGDPIGDQWEEEEGGFNYAVDLVKHIRSEFGDYFDICVAGYPKGHPEAGSFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEVPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDPRRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFEVFVLYLSGEPNRNGHKVTCLPWNDEPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPIVGWGPSGGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYFLVNLVDNDFPLDNCLWQVVEDTLELLNRPTQNARETEAP
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp469800MTHFRmethylenetetrahydrofolate reductase9598VGNC:14309OMA, EggNOG
Macaque714840MTHFRmethylenetetrahydrofolate reductase9544Inparanoid, OMA, EggNOG
Mouse17769Mthfrmethylenetetrahydrofolate reductase10090MGI:106639Inparanoid, OMA, EggNOG
Rat362657Mthfrmethylenetetrahydrofolate reductase10116RGD:1309952Inparanoid, OMA, EggNOG
Dog478230MTHFRmethylenetetrahydrofolate reductase9615VGNC:43473Inparanoid, OMA, EggNOG
Horse100050979MTHFRmethylenetetrahydrofolate reductase9796VGNC:20415Inparanoid, OMA, EggNOG
Cow497032MTHFRmethylenetetrahydrofolate reductase9913VGNC:31731Inparanoid, OMA, EggNOG
Pig397180MTHFRmethylenetetrahydrofolate reductase9823Inparanoid, OMA, EggNOG
Opossum100018128MTHFRmethylenetetrahydrofolate reductase13616Inparanoid, OMA, EggNOG
Platypus100086119MTHFRmethylenetetrahydrofolate reductase9258Inparanoid, OMA, EggNOG
Chicken419489MTHFRmethylenetetrahydrofolate reductase9031CGNC:3409OMA, EggNOG
Xenopus100125082mthfrmethylenetetrahydrofolate reductase (NAD(P)H)8364XB-GENE-1005402Inparanoid, OMA, EggNOG
Zebrafish567547mthfrmethylenetetrahydrofolate reductase (NAD(P)H)7955ZDB-GENE-041111-215Inparanoid, OMA, EggNOG
C. elegans174254mthf-1Probable methylenetetrahydrofolate reductase6239Inparanoid, OMA, EggNOG
S.cerevisiae852752MET13methylenetetrahydrofolate reductase (NAD(P)H) MET134932S000003093Inparanoid, OMA, EggNOG

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      🔙[Back to Target (Human)]
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