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| Description | Serine/threonine-protein kinase/endoribonuclease IRE1 |
|---|
Gene and Protein Information
| Gene ID | 2081 |
|---|---|
| Uniprot Accession IDs | O75460 A1L457 A8K8N8 A8MXS7 Q59EE2 |
| Ensembl ID | ENSP00000401445 |
| Symbol | IRE1 IRE1 IRE1P IRE1a hIRE1p |
| Family | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. |
| Sequence | MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPPEPQPPVTPDAL Show more |
Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
|---|---|---|---|---|---|---|
| Chimp | 454769 | ERN1 | endoplasmic reticulum to nucleus signaling 1 | 9598 | VGNC:14501 | OMA, EggNOG |
| Macaque | 717751 | ERN1 | endoplasmic reticulum to nucleus signaling 1 | 9544 | Inparanoid, OMA, EggNOG | |
| Mouse | 78943 | Ern1 | endoplasmic reticulum (ER) to nucleus signalling 1 | 10090 | MGI:1930134 | Inparanoid, OMA, EggNOG |
| Rat | 498013 | Ern1 | endoplasmic reticulum to nucleus signaling 1 | 10116 | RGD:1559716 | Inparanoid, OMA, EggNOG |
| Dog | 610766 | ERN1 | endoplasmic reticulum to nucleus signaling 1 | 9615 | VGNC:40464 | Inparanoid, OMA, EggNOG |
| Horse | 100064339 | ERN1 | endoplasmic reticulum to nucleus signaling 1 | 9796 | VGNC:17673 | Inparanoid, OMA, EggNOG |
| Cow | ERN1 | endoplasmic reticulum to nucleus signaling 1 [Source:HGNC Symbol;Acc:HGNC:3449] | 9913 | OMA, EggNOG | ||
| Pig | 100510978 | ERN1 | endoplasmic reticulum to nucleus signaling 1 | 9823 | Inparanoid, OMA, EggNOG | |
| Opossum | 100026418 | ERN1 | endoplasmic reticulum to nucleus signaling 1 | 13616 | Inparanoid, OMA, EggNOG | |
| Anole lizard | 100566768 | ern1 | endoplasmic reticulum to nucleus signaling 1 | 28377 | Inparanoid, OMA | |
| Zebrafish | 553551 | ern1 | endoplasmic reticulum to nucleus signaling 1 | 7955 | ZDB-GENE-050522-431 | Inparanoid, OMA |
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Availability | View Details |
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Associated Antibodies
| Name | Specifications | Species reactivity | Application | Availability | View Details |
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Associated Approved Drugs
Associated Active Ligands
Associated Diseases
| Name | Direct Associated Targets | Disease Type | Mondoid |
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Bibliography
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