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TOP2B

DescriptionDNA topoisomerase 2-beta

Gene and Protein Information

Gene ID7155
Uniprot Accession IDs Q02880 Q13600 Q9UMG8 Q9UQP8
Ensembl ID ENSP00000396704
Symbol TOPIIB top2beta
FamilyBelongs to the type II topoisomerase family.
Sequence
MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDVDFAMFN
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp460232TOP2BDNA topoisomerase II beta9598VGNC:8848OMA, EggNOG
Macaque677709TOP2BDNA topoisomerase II beta9544Inparanoid, OMA, EggNOG
Mouse21974Top2btopoisomerase (DNA) II beta10090MGI:98791Inparanoid, OMA, EggNOG
Dog477044TOP2BDNA topoisomerase II beta9615VGNC:49632Inparanoid, OMA, EggNOG
Horse100059572TOP2BDNA topoisomerase II beta9796VGNC:50517Inparanoid, OMA, EggNOG
Cow282097TOP2BDNA topoisomerase II beta9913VGNC:49158Inparanoid, OMA, EggNOG
Pig100156319TOP2BDNA topoisomerase II beta9823OMA, EggNOG
Opossum100031654TOP2BDNA topoisomerase II beta13616Inparanoid, OMA, EggNOG
Platypus100075740TOP2BDNA topoisomerase II beta9258Inparanoid, OMA, EggNOG
Anole lizard100563490top2bDNA topoisomerase II beta28377Inparanoid, OMA
Xenopus779457top2bDNA topoisomerase II beta8364XB-GENE-940716Inparanoid, OMA
Xenopus100038293top2aDNA topoisomerase II alpha8364XB-GENE-970178OMA, EggNOG
Zebrafish569877top2bDNA topoisomerase II beta7955ZDB-GENE-041008-136Inparanoid, OMA, EggNOG
C. elegans174825top-2Probable DNA topoisomerase 26239Inparanoid, OMA
Fruitfly35225Top2Topoisomerase 27227FBgn0284220Inparanoid, OMA, EggNOG
S.cerevisiae855636TOP2DNA topoisomerase 24932S000005032Inparanoid, OMA, EggNOG

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      🔙[Back to Target (Human)]
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