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GEN1

DescriptionFlap endonuclease GEN homolog 1

Gene and Protein Information

Gene ID348654
Uniprot Accession IDs Q17RS7 Q17RS9 Q6ZN37
Ensembl ID ENSP00000318977
Symbol Gen
FamilyBelongs to the XPG/RAD2 endonuclease family. GEN subfamily.
Sequence
MGVNDLWQILEPVKQHIPLRNLGGKTIAVDLSLWVCEAQTVKKMMGSVMKPHLRNLFFRISYLTQMDVKLVFVMEGEPPKLKADVISKRNQSRYGSSGKSWSQKTGRSHFKSVLRECLHMLECLGIPWVQAAGEAEAMCAYLNAGGHVDGCLTNDGDTFLYGAQTVYRNFTMNTKDPHVDCYTMSSIKSKLGLDRDALVGLAILLGCDYLPKGVPGVGKEQALKLIQILKGQSLLQRFNRWNETSCNSSPQLLVTKKLAHCSVCSHPGSPKDHERNGCRLCKSDKYCEPHDYEYCCPCEWHRTEHDRQLSEVENNIKKKACCCEGFPFHEVIQEFLLNKDKLVKVIRYQRPDLLLFQRFTLEKMEWPNHYACEKLLVLLTHYDMIERKLGSRNSNQLQPIRIVKTRIRNGVHCFEIEWEKPEHYAMEDKQHGEFALLTIEEESLFEAAYPEIVAVYQKQKLEIKGKKQKRIKPKENNLPEPDEVMSFQSHMTLKPTCEIFHKQNSKLNSGISPDPTLPQESISASLNSLLLPKNTPCLNAQEQFMSSLRPLAIQQIKAVSKSLISESSQPNTSSHNISVIADLHLSTIDWEGTSFSNSPAIQRNTFSHDLKSEVESELSAIPDGFENIPEQLSCESERYTANIKKVLDEDSDGISPEEHLLSGITDLCLQDLPLKERIFTKLSYPQDNLQPDVNLKTLSILSVKESCIANSGSDCTSHLSKDLPGIPLQNESRDSKILKGDQLLQEDYKVNTSVPYSVSNTVVKTCNVRPPNTALDHSRKVDMQTTRKILMKKSVCLDRHSSDEQSAPVFGKAKYTTQRMKHSSQKHNSSHFKESGHNKLSSPKIHIKETEQCVRSYETAENEESCFPDSTKSSLSSLQCHKKENNSGTCLDSPLPLRQRLKLRFQST
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp470313GEN1GEN1, Holliday junction 5' flap endonuclease9598VGNC:271OMA, EggNOG
Macaque699692GEN1GEN1, Holliday junction 5' flap endonuclease9544Inparanoid, OMA, EggNOG
Mouse209334Gen1GEN1, Holliday junction 5' flap endonuclease10090MGI:2443149Inparanoid, OMA, EggNOG
Rat298884Gen1GEN1 Holliday junction 5' flap endonuclease10116RGD:1559792Inparanoid, OMA, EggNOG
Dog482980GEN1GEN1, Holliday junction 5' flap endonuclease9615VGNC:41179Inparanoid, OMA, EggNOG
Horse100072048GEN1GEN1, Holliday junction 5' flap endonuclease9796VGNC:18308Inparanoid, OMA, EggNOG
Cow785690GEN1GEN1, Holliday junction 5' flap endonuclease9913VGNC:29322Inparanoid, OMA, EggNOG
Pig100517338GEN1GEN1, Holliday junction 5' flap endonuclease9823Inparanoid, OMA, EggNOG
Anole lizard100561546gen1GEN1, Holliday junction 5' flap endonuclease28377Inparanoid, OMA, EggNOG
Xenopusgen1GEN1, Holliday junction 5' flap endonuclease [Source:Xenbase;Acc:XB-GENE-940145]8364OMA, EggNOG
Fruitfly38594GenXPG-like endonuclease7227FBgn0263831Inparanoid, EggNOG

Protein Classes

PANTHER Classes
protein    /    nucleic acid binding    /    damaged DNA-binding protein    /    Flap endonuclease GEN homolog 1
protein    /    nucleic acid binding    /    exodeoxyribonuclease    /    Flap endonuclease GEN homolog 1
protein    /    nucleic acid binding    /    endodeoxyribonuclease    /    Flap endonuclease GEN homolog 1
protein    /    nucleic acid binding    /    nuclease    /    Flap endonuclease GEN homolog 1
protein    /    nucleic acid binding    /    hydrolase    /    Flap endonuclease GEN homolog 1
DTO Classes
protein    /    Enzyme    /    Nuclease    /    Exodeoxyribonuclease    /    Flap endonuclease GEN homolog 1

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      🔙[Back to Target (Human)]
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