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· · COA & SDS available for every product · Same-day shipping on in-stock items TC JL 37 - ≥98%(HPLC) , CAS No.1258294-34-6
Synonyms
2-Chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]benzamide
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Why this grade ≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
2-Chloro-4-cyano-6-fluoro-N-[2-[[[(1R, 2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]benzamide
Specifications & Purity
≥98%(HPLC)
Biochemical and Physiological Mechanisms
Potent inhibitor of tyrosine kinase 2 (TYK2, Ki= 1.6 nM). Shows some selectivity for TYK2 over JAK1/2/3. Inhibits IFNγ productionin vivoin mice. Orally bioavailable.
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers Canonical Smiles C1C(C1F)C(=O)NC2=NC=CC(=C2)NC(=O)C3=C(C=C(C=C3Cl)C#N)F IUPAC Name 2-chloro-4-cyano-6-fluoro-N-[2-[[(1R,2R)-2-fluorocyclopropanecarbonyl]amino]pyridin-4-yl]benzamide InChIKey NKALKXMQBFLGQI-CMPLNLGQSA-N INCHI 1S/C17H11ClF2N4O2/c18-11-3-8(7-21)4-13(20)15(11)17(26)23-9-1-2-22-14(5-9)24-16(25)10-6-12(10)19/h1-5,10,12H,6H2,(H2,22,23,24,25,26)/t10-,12+/m0/s1 Isomeric SMILES C1[C@@H]([C@@H]1F)C(=O)NC2=NC=CC(=C2)NC(=O)C3=C(C=C(C=C3Cl)C#N)F PubChem CID 56934550 Molecular Weight 376.74
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Benzenoids Class Benzene and substituted derivatives Subclass Benzoic acids and derivatives Intermediate Tree Nodes Halobenzoic acids and derivatives Direct Parent 2-halobenzoic acids and derivatives Alternative Parents Benzamides Benzonitriles Benzoyl derivatives N-arylamides Chlorobenzenes Fluorobenzenes Aryl chlorides Aryl fluorides Pyridines and derivatives Imidolactams Cyclopropanecarboxylic acids and derivatives Vinylogous halides Heteroaromatic compounds Secondary carboxylic acid amides Nitriles Azacyclic compounds Carbonyl compounds Organic oxides Organochlorides Organofluorides Hydrocarbon derivatives Alkyl fluorides Molecular Framework Aromatic heteromonocyclic compounds Substituents 2-halobenzoic acid or derivatives - Benzamide - Benzoyl - N-arylamide - Benzonitrile - Fluorobenzene - Halobenzene - Chlorobenzene - Imidolactam - Aryl halide - Aryl fluoride - Pyridine - Aryl chloride - Cyclopropanecarboxylic acid or derivatives - Vinylogous halide - Heteroaromatic compound - Secondary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Carbonitrile - Nitrile - Organoheterocyclic compound - Azacycle - Alkyl fluoride - Organohalogen compound - Organochloride - Organofluoride - Organonitrogen compound - Carbonyl group - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Cyanide - Organic oxygen compound - Organic nitrogen compound - Alkyl halide - Aromatic heteromonocyclic compound Description This compound belongs to the class of organic compounds known as 2-halobenzoic acids and derivatives. These are benzoic acids or derivatives carrying a halogen atom at the 2-position of the benzene ring. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 37.67, Max Conc. mM: 100 Molecular Weight 376.700 g/mol XLogP3 2.200 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6 Rotatable Bond Count 4 Exact Mass 376.054 Da Monoisotopic Mass 376.054 Da Topological Polar Surface Area 94.900 Ų Heavy Atom Count 26 Formal Charge 0 Complexity 613.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 2 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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