Telomerase-IN-1 - ≥99% , CAS No.666859-49-0

CAS: 666859-49-0 Cat. No.: T650536 Molecular Weight: 386.42

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Overview

Telomerase-IN-1 is a Telomerase inhibitor with an IC 50 of 0.19 μM.

In Vitro

Our in vitro studies show that title compound (Telomerase-IN-1) has high inhibitory activity against telomerase and high antiproliferative capacity on SMMC-7721 cells, and has no obvious toxic effect on human normal hepatocyte cells. Telomerase-IN-1 treatment decreases the growth of cancer cells in dose- and time-dependent manners; however, the viability of L-02 shows slight changes in the compound at 10 μM. 48 h of SMMC-7721 cell treatment with the Telomerase-IN-1 (20, 40, and 80 nM) causes increase of apoptosis. Forty-eight hours of SMMC-7721 cell treatment with the Telomerase-IN-1(20, 40, and 80 nM) causes significant accumulation of green fluorescence, indicating a decrease in MMP. At 40 nM, Telomerase-IN-1 significantly increases expressions of cyt-c and Bax, but the Bcl-2 level is decreased. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Our in vivo studies show that this compound (Telomerase-IN-1) significantly inhibits tumor growth in xenograft tumor models. Results show that endoplasmic reticulum stress (ERS) through ER over response (EOR) activates the expression of hTERT, and then induces ERS, which is believed to be intricately associated with oxidative stress and mitochondrial dysfunction, resulting in apoptotic cell death, thereby modulating the expression of downstream signaling molecules including CHOP (CAAT/enhancer-binding protein homologous protein)) and mitochondrion pathway of apoptosis, leading to inhibition of cell proliferation . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 0.19 μM (Telomerase)

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Telomerase-IN-1 is a Telomerase inhibitor with an IC 50 of 0.19 μM.

Storage

Store at 2-8°C, Protected from light, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: O=C(C1=CC=C(F)C=C1)C2CCN(CC(OC)C3=CC=C([N+]([O-])=O)C=C3)CC2
• Molecular Weight: 386.42

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (258.79 mM; Need ultrasonic)