A high affinity blocker for inward-rectifier K+channels, this compound is a stable derivative of the bee venom toxin tertiapin. Binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Kivalues are 1.3 and 13.3 nM respectively) and is
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