Tetracaine HCl - 10mM in DMSO , Sodium channel alpha subunit blocker, CAS No.136-47-0, Sodium channel alpha subunit blocker

CAS: 136-47-0 Cat. No.: T408312 Molecular Weight: 300.82 EC Number: 205-248-5 PubChem CID: 8695

GRADE & PURITY 10mM in DMSO

Synonyms

Amethocalne HCl | 4-​(butylamino)​-​benzoic acid 2-​(dimethylamino)​ethyl ester, hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Tetracaine HCl Tetracaine HCl (Amethocalne) is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Amethocalne HCl | 4-​(butylamino)​-​benzoic acid 2-​(dimethylamino)​ethyl ester, hydrochloride (1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Tetracaine HCl (Amethocalne) is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

BLOCKER

Mechanism of action

Sodium channel alpha subunit blocker

Names and Identifiers

• Isomeric SMILES: CCCCNC1=CC=C(C=C1)C(=O)OCCN(C)C.Cl
• WGK Germany: 3
• RTECS: DG4900000
• PubChem CID: 8695
• UN Number: 2811
• Molecular Weight: 300.82
• Reaxy-Rn: 3918400

Chemical and Physical Properties

• Melt Point(°C): 149°C

References

1. Zhanyi Yang, Shiqi He, Jiajun Wang, Yi Yang, Licong Zhang, Yanbing Li, Anshan Shan.  (2019)  Rational Design of Short Peptide Variants by Using Kunitzin-RE, an Amphibian-Derived Bioactivity Peptide, for Acquired Potent Broad-Spectrum Antimicrobial and Improved Therapeutic Potential of Commensalism Coinfection of Pathogens.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:30958004] [10.1021/acs.jmedchem.9b00149]

2. Xiaokang Guan, Qiao Lu, Xiangxu Zhao, Xiaowen Yan, Renato Zenobi.  (2023)  Spatio-Temporal Analysis of Anesthetics in Mice by Solid-Phase Microextraction: Dielectric Barrier Discharge Ionization Mass Spectrometry.  ANALYTICAL CHEMISTRY,      [PMID:37560898] [10.1021/acs.analchem.3c02123]

3. Kun Chen, Guixin Wang, Xuedong Wang, Huili Wang.  (2023)  A smartphone-based ratiometric fluoroprobe based on blue-red dual-emission signals of thiochrome and copper nanoclusters for sensitive assay of metam-sodium in cucumbers.  TALANTA,      [PMID:37207510] [10.1016/j.talanta.2023.124673]

4. Lin-Ping Xue, Hai-Song Feng.  (2025)  HMGB2 knockdown ameliorates retinal ganglion cell injury by inhibiting NLRP3 inflammasome activation after retinal ischemia.  International Journal of Ophthalmology,  18  (1): (39).  [PMID:39829613] [10.18240/ijo.2025.01.05]