Tolfenamic Acid - Moligand™, 10mM in DMSO , Inhibitor of AKR1C3, CAS No.13710-19-5, Inhibitor of AKR1C3

CAS: 13710-19-5 Cat. No.: T407845 Molecular Weight: 261.7 EC Number: 237-264-3 PubChem CID: 610479

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

2-​[(3-​chloro-​2-​methylphenyl)​amino]​-benzoic acid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Tolfenamic Acid is aCOX-2inhibitor withIC50of 0.2 μM.
In vitro

In vivo

Cell Data

cell lines：RF/MT-2 strains

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyms

2-​[(3-​chloro-​2-​methylphenyl)​amino]​-benzoic acid

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of AKR1C3

Names and Identifiers

• Isomeric SMILES: CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O
• WGK Germany: 3
• RTECS: CB2687500
• PubChem CID: 610479
• Molecular Weight: 261.7
• Reaxy-Rn: 657821

Associated Targets(Human)

TTR Tclin Transthyretin (1 Activities)

Discover Target: TTR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1C3 Tchem Aldo-keto reductase family 1 member C3 (2 Activities)

Discover Target: AKR1C3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 62 mg/mL (186.25 mM)
• Melt Point(°C): 209-214°C

References

1. Guanqiong Na, Xiaofei Hu, Yaning Sun, Guangxu Xing, Yunrui Xing, Gaiping Zhang.  (2020)  A novel gold particle-based paper sensor for sensitively detecting carprofen in bovine muscle.  FOOD AND AGRICULTURAL IMMUNOLOGY,      [PMID:] [10.1080/09540105.2020.1740178]

2. Xinyi Wang, Shijie Xu, Lina Jia, Yujia Yang, Yu Liu, Junbo Gong, Songgu Wu.  (2019)  Drug–drug salts of mefenamic acid\tolfenamic acid and piperazine to improve physicochemical properties for potential veterinary use.  CRYSTENGCOMM,  21  (35): (5284-5291).  [PMID:] [10.1039/C9CE00781D]

3. Xue Shu-Wen, Li Jing, Xu Li.  (2017)  Preparation of magnetic melamine-formaldehyde resin and its application to extract nonsteroidal anti-inflammatory drugs.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  409  (12): (3103-3113).  [PMID:28224244] [10.1007/s00216-017-0251-8]

4. Luo Zhi-yuan, Li Zhi-yong, Liu Hai-yan, Tang Min-qiong, Shi Zhi-guo.  (2015)  Click chemistry-based synthesis of water-dispersible hydrophobic magnetic nanoparticles for use in solid phase extraction of non-steroidal anti-inflammatory drugs.  MICROCHIMICA ACTA,  182  (15): (2585-2591).  [PMID:] [10.1007/s00604-015-1638-x]