TP-238 hydrochloride - ≥98% , CAS No.2415263-05-5

CAS: 2415263-05-5 Cat. No.: T648473 Formula: C₂₂H₃₁ClN₆O₃S Molecular Weight: 495.04 PubChem CID: 146018950

GRADE & PURITY ≥98%

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

TP-238 hydrochloride is a potent and selective dual CECR2/BPTF probe with IC 50 values of 30 nM and 350 nM, respectively. TP-238 hydrochloride also inhibits BRD9 with a pIC 50 of 5.9 and is less active against other 338 kinases

In Vitro

TP-238 has on target biochemical activity of 10-30 nM with CECR2 and 100-350 nM with BPTF. TP-238 displays potency for both CECR2 (pIC50 of 7.5) and BPTF (pIC50 of 6.5) in an Alpha screen assay. Isothermal titration calorimetry (ITC) shows TP-238 with a Kd of 10 nM for CECR2 and 120 nM for BPTF . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:CECR2|30 nM (IC|50|)|CECR2|10 nM (Kd)|CECR2|7.5 (pIC|50|)|BPTF|350 nM (IC|50|)|BPTF|120 nM (Kd)|BPTF|6.5 (pIC|50|)|BRD9|5.9 (pIC|50|)

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

TP-238 hydrochloride is a potent and selective dual CECR2/BPTF probe with IC 50 values of 30 nM and 350 nM, respectively. TP-238 hydrochloride also inhibits BRD9 with a pIC 50 of 5.9 and is less active against other 338 kinases.

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CN(C)CCCOC1=CC=C(C=C1)C2=CC(=NC(=N2)S(=O)(=O)C)NCCCN3C=CC=N3.Cl
• IUPAC Name: 6-[4-[3-(dimethylamino)propoxy]phenyl]-2-methylsulfonyl-N-(3-pyrazol-1-ylpropyl)pyrimidin-4-amine;hydrochloride
• InChIKey: FHVADRKEPFRFFF-UHFFFAOYSA-N
• INCHI: 1S/C22H30N6O3S.ClH/c1-27(2)13-6-16-31-19-9-7-18(8-10-19)20-17-21(26-22(25-20)32(3,29)30)23-11-4-14-28-15-5-12-24-28;/h5,7-10,12,15,17H,4,6,11,13-14,16H2,1-3H3,(H,23,25,26);1H
• PubChem CID: 146018950
• Molecular Weight: 495.04

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (202.00 mM; Need ultrasonic)

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2415263-05-5, the molecular formula is C22H31ClN6O3S, and the molecular weight is 495.04 g/mol. InChIKey FHVADRKEPFRFFF-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.