TRAP-6 - 10mM in Water , CAS No.141136-83-6

CAS: 141136-83-6 Cat. No.: T655678 Molecular Weight: 748.88 PubChem CID: 9831933

GRADE & PURITY 10mM in Water

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor . TRAP-6 shows no activity at PAR4

In Vitro

TRAP-6 (0.01-10 μM) triggers calcium mobilization in Xenopus oocytes heterologously expressing PAR1. TRAP-6 (0.01-10 μM; 30 min) activates human platelets. TRAP-6 (100 μM) does not cause the platelets of rabbits or rats to change shape, aggregate, release granule contents, or form thromboxane. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TRAP (1 mg/kg; i.v.) produces a biphasic response in blood pressure in inactin-anesthetized rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:PAR1

Specifications

Specifications & Purity

10mM in Water

Biochemical and Physiological Mechanisms

TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor . TRAP-6 shows no activity at PAR4.

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CO)N
• PubChem CID: 9831933
• Molecular Weight: 748.88