≥96% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 5 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Tri-o-tolyl phosphate is classified under the class of non-halogenated organophosphate esters (OPE）
Purpose
Tri-o-tolyl phosphate may be used as an analytical reference standard for the determination of tri-o-tolyl phosphate in:
Analysis of tri-o-tolyl phosphate in edible oils by TLC and GC is described in methods FSSAI 02.036:2021 and FSSAI 02.037:2021
Surface water and wastewater effluent samples by liquid chromatography coupled to tandem mass spectrometry equipped with electrospray ionization (LC-ESI-MS/MS) operating under the multiple reaction monitoring (MRM) mode of detection.
Human hair and nails by liquid-liquid extraction (LLE) and gas chromatography-mass spectrometry (GC-MS).
Indoor air, dust and window wipes by GC-MS/MS
Outdoor air samples by ultra-performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-QqQ-MS/MS) equipped with ESI source and MRM detection
| Pubchem Sid | 504751112 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504751112 |
| Canonical Smiles | CC1=CC=CC=C1OP(=O)(OC2=CC=CC=C2C)OC3=CC=CC=C3C |
| IUPAC Name | tris(2-methylphenyl) phosphate |
| InChIKey | YSMRWXYRXBRSND-UHFFFAOYSA-N |
| INCHI | 1S/C21H21O4P/c1-16-10-4-7-13-19(16)23-26(22,24-20-14-8-5-11-17(20)2)25-21-15-9-6-12-18(21)3/h4-15H,1-3H3 |
| Isomeric SMILES | CC1=CC=CC=C1OP(=O)(OC2=CC=CC=C2C)OC3=CC=CC=C3C |
| RTECS | TD0350000 |
| UN Number | 2574 |
| Packing Group | II |
| Molecular Weight | 368.37 |
| Reaxy-Rn | 1892885 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Class | Organic phosphoric acids and derivatives |
| Subclass | Phosphate esters |
| Intermediate Tree Nodes | Aryl phosphates |
| Direct Parent | Aryl phosphotriesters |
| Alternative Parents | Phenoxy compounds Toluenes Organooxygen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Aryl phosphotriester - Phenoxy compound - Toluene - Benzenoid - Monocyclic benzene moiety - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as aryl phosphotriesters. These are aryl phosphates in which the phosphate is esterified at exactly three positions. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 K2512557 | Certificate of Analysis | Oct 11, 2025 | T121610 |
| K2512559 | Certificate of Analysis | Oct 11, 2025 | T121610 |
| K2512565 | Certificate of Analysis | Oct 11, 2025 | T121610 |
| K2129303 | Certificate of Analysis | Sep 08, 2025 | T121610 |
| K2316354 | Certificate of Analysis | Nov 06, 2023 | T121610 |
| K2316355 | Certificate of Analysis | Nov 06, 2023 | T121610 |
| I1510100 | Certificate of Analysis | May 06, 2023 | T121610 |
| Solubility | Insoluble in water; Soluble in Ether,Alcohol |
|---|---|
| Sensitivity | Light sensitive |
| Refractive Index | 1.56 |
| Flash Point(°F) | 230.0 °F |
| Flash Point(°C) | 110 °C |
| Boil Point(°C) | 410°C |
| Molecular Weight | 368.400 g/mol |
| XLogP3 | 6.100 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 6 |
| Exact Mass | 368.118 Da |
| Monoisotopic Mass | 368.118 Da |
| Topological Polar Surface Area | 44.800 Ų |
| Heavy Atom Count | 26 |
| Formal Charge | 0 |
| Complexity | 416.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Yijing Wu, Wenjun Zheng, Canrong Chen, Linyan Yang, Ping Tong, Yanhui Zhong, Zian Lin, Zongwei Cai. (2023) Facile synthesis of spherical covalent organic frameworks for enrichment and quantification of aryl organophosphate esters in mouse serum and tissues. JOURNAL OF SEPARATION SCIENCE, 46 (22): (2300482). [PMID:37727055] [10.1002/jssc.202300482] |
| 2. Xun’e Yi, Haiyu Qin, Guangyu Li, Ren Kong, Chunsheng Liu. (2024) Isomer-specific cardiotoxicity induced by tricresyl phosphate in zebrafish embryos/larvae. JOURNAL OF HAZARDOUS MATERIALS, [PMID:38823104] [10.1016/j.jhazmat.2024.134753] |
| 3. Xiangsheng Tian, Yiquan Ou, Shengyuan Shi, Qiuhua Zhou, Sihong Long, Yao Xiang, Weichao Zhao, Dingxin Long. (2024) SIRT1-Dependent Neuroprotection by Resveratrol in TOCP-Induced Spinal Cord Injury: Modulation of ER Stress and Autophagic Flux. Toxics, 12 (11): (810). [PMID:39590990] [10.3390/toxics12110810] |
| 4. Zelin Zhu, Xiuping Qi, Zhihao Zhang, Xuanyu Dou, Xinxin Jiang, Yutong Liu, Shencheng Fu, Xintong Zhang, Yichun Liu. (2024) Ultra-High Secure Holographically Steganographic Array with Spatiotemporal Dual-Encryption Keys. ADVANCED FUNCTIONAL MATERIALS, [PMID:] [10.1002/adfm.202414352] |
| 5. Sangping Li, Shule Tan, Xiangsheng Tian, Yiquan Ou, Shujuan Hu, Weichao Zhao, Dingxin Long. (2025) Resveratrol mitigates TOCP-induced spinal cord neurotoxicity by suppressing ferroptosis, a process mediated through the p62/Keap1/Nrf2 pathway. TOXICOLOGY AND APPLIED PHARMACOLOGY, [PMID:41475526] [10.1016/j.taap.2025.117698] |
