Triamcinolone Acetonide - Moligand™, 10mM in DMSO , Glucocorticoid receptor agonist, CAS No.76-25-5, Glucocorticoid receptor agonist

CAS: 76-25-5 Cat. No.: T408371 Molecular Weight: 434.50 EC Number: 200-948-7 PubChem CID: 6436

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(11β,​16α)​-9-​fluoro-​11,​21-​dihydroxy-​16,​17-​[(1-​methylethylidene)​bis(oxy)​]​-pregna-​1,​4-​diene-​3,​20-​dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Triamcinolone Acetonide Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.
In vitro

Triamcinolone Acetonide significantly decreases the paracellular permeability of ECV304 cells and down-regulated ICAM-1 expression, consistent with immunocytochemical observations. Triamcinolone reverses the osmotic swelling of glial cells in retinas of the rat that is observed under various experimental conditions: in retinas isolated at 3 days after transient retinal ischemia, in retinas of eyes with lipopolysaccharide-induced ocular inflammation, and in control retinas in the presence of Ba^{2+ (1 mM), H₂O₂ (200 mM), arachidonic acid (10 mM), or prostaglandin E2 (30 nM). Triamcinolone Acetonide reduces GAG synthesis compared to control and IL-1 alone. Triamcinolone Acetonide increases GAG degradation. Triamcinolone Acetonide increases media GAG content compared to control and IL-1 explants.}

In vivo

Triamcinolone Acetonide (TAC), a synthetic glucocorticoid, induces cleft palate resulting from poor development of palatal shelves in mice. Triamcinolone Acetonide inhibits the proliferation of mesenchymal cells and affects the differentiation of MEE cells into stratified squamous epithelia in the palatal shelves of rat embryos. Triamcinolone Acetonide reduces lameness, edema, and concentration of synovial fluid protein after the second LPS injection in horse. Triamcinolone Acetonide also induces higher WBC counts and mepivacaine concentrations in synovial fluid, compared with results for Mepivacaine alone.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

(11β, ​16α)​-9-​fluoro-​11, ​21-​dihydroxy-​16, ​17-​[(1-​methylethylidene)​bis(oxy)​]​-pregna-​1, ​4-​diene-​3, ​20-​dione

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Glucocorticoid receptor agonist

Product Properties

• ALogP: 2.5

Names and Identifiers

• Isomeric SMILES: C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)CCC5=CC(=O)C=C[C@@]53C)F)O
• WGK Germany: 3
• RTECS: TU3920000
• PubChem CID: 6436
• Molecular Weight: 434.50

Associated Targets(Human)

NR3C1 Tclin Glucocorticoid receptor (3 Activities)

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Sensitivity: Lght Sensitive
• Melt Point(°C): 274-278℃

References

1. Qu Xiaoying, Guo Xiaoli, Zhu Tingting, Zhang Zhe, Wang Wanchun, Hao Yuanping.  (2023)  Microneedle patches containing mesoporous polydopamine nanoparticles loaded with triamcinolone acetonide for the treatment of oral mucositis.  Frontiers in Bioengineering and Biotechnology,      [PMID:37214298] [10.3389/fbioe.2023.1203709]

2. Beibei Yang, Yating Dong, Yifeng Shen, Ailin Hou, Guilan Quan, Xin Pan, Chuanbin Wu.  (2021)  Bilayer dissolving microneedle array containing 5-fluorouracil and triamcinolone with biphasic release profile for hypertrophic scar therapy.  Bioactive Materials,      [PMID:33553824] [10.1016/j.bioactmat.2021.01.014]

3. Youfang Huang, Yanyun Li, Qing Luo, Xiaojia Huang.  (2020)  One-step preparation of functional groups-rich graphene oxide and carbon nanotubes nanocomposite for efficient magnetic solid phase extraction of glucocorticoids in environmental waters.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2020.126785]

4. Guihua Gao, Sijia Li, Shuo Li, Yudan Wang, Pan Zhao, Xiangyu Zhang, Xiaohong Hou.  (2017)  A combination of computational−experimental study on metal-organic frameworks MIL-53(Al) as sorbent for simultaneous determination of estrogens and glucocorticoids in water and urine samples by dispersive micro-solid-phase extraction coupled to UPLC-MS/MS.  TALANTA,      [PMID:29332823] [10.1016/j.talanta.2017.12.071]

5. Yuhang Wang, Jiang Yu, Xuejing Li, Haolin Zhang, Tengfei Zhou, Yiguo Jiang, Yongjun Wang.  (2025)  Enhanced inflammatory arthritis therapy with gallic acid-modified triamcinolone acetonide: A sucrose acetate isobutyrate-based sustained release depot.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2025.106719]

6. Baozhang Shi, Hao Wei, Hongyue Miu, Liangliang Li, Jianing Zhu, Yubing Huo, Liping Xu, Wei Sun.  (2024)  Fabrication of micro-porous polymeric coating with dynamic drug-eluting property on plastic biliary stent for antiproliferative treatment.  Colloid and Interface Science Communications,      [PMID:] [10.1016/j.colcom.2024.100801]