Triisopropanolamine（TIPA） - ≥95%, mixture of isomer , CAS No.122-20-3

CAS: 122-20-3 Cat. No.: T105008 Molecular Weight: 191.27 Beilstein Registry Number: 1071570 EC Number: 204-528-4

GRADE & PURITY ≥95%, mixture of isomer

Synonyms

1,1 ",1 "-triazo (-2-propyl alcohol) | Tri (2-hydroxypropyl) amine | Nitrilotripropanol (mixture of isomer)

Storage

Argon charged,Room temperature

Shipped In

Normal

Overview

Triisopropanolamine (TIPA), a tertiary alkanolamine, is majorly used as a grinding chemical that reduces agglomeration in the ball milling process and changes the particle distribution of the finished cement.
Application
TIPA can act as an interfacial transition zone (ITZ) to improve the mechanical properties of the mortar and the concrete. It can also be used to increase the compressive strength of the cement-fly ash system by accelerating the hydration of both the compounds.

Specifications

Synonyms

1, 1 ", 1 "-triazo (-2-propyl alcohol) | Tri (2-hydroxypropyl) amine | Nitrilotripropanol (mixture of isomer)

Specifications & Purity

≥95%, mixture of isomer

Storage

Argon charged, Room temperature

Shipped In

Normal

Purity

≥95%

Names and Identifiers

• Pubchem Sid: 504753253
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504753253
• Canonical Smiles: CC(CN(CC(C)O)CC(C)O)O
• IUPAC Name: 1-[bis(2-hydroxypropyl)amino]propan-2-ol
• InChIKey: SLINHMUFWFWBMU-UHFFFAOYSA-N
• INCHI: 1S/C9H21NO3/c1-7(11)4-10(5-8(2)12)6-9(3)13/h7-9,11-13H,4-6H2,1-3H3
• Isomeric SMILES: CC(CN(CC(C)O)CC(C)O)O
• WGK Germany: 1
• RTECS: UB8750000
• Molecular Weight: 191.27
• Beilstein: 1071570

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Class Organonitrogen compounds
      • Subclass Amines
        • Level5 Alkanolamines
          • Level6 1,2-aminoalcohols

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Class: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Alkanolamines
• Direct Parent: 1,2-aminoalcohols
• Alternative Parents: Trialkylamines Secondary alcohols Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Tertiary aliphatic amine - Tertiary amine - Secondary alcohol - 1,2-aminoalcohol - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Alcohol - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

AR Tclin Androgen Receptor (11781 Activities)

Discover Target: AR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water (>1000 mg/ml at 25 °C), ethanol, diethyl ether, chloroform (slightly ), and methanol (>500 g/100g).
• Sensitivity: Hygroscopic
• Flash Point(°F): 320(°F)
• Flash Point(°C): 160°C
• Boil Point(°C): 190°C
• Melt Point(°C): 48-52°C
• Molecular Weight: 191.270 g/mol
• XLogP3: -0.500
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 191.152 Da
• Monoisotopic Mass: 191.152 Da
• Topological Polar Surface Area: 63.900 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 108.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 3
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

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3. Zhang Feng, Bai Yin, Cai Yuebo, Chen Bo, Ning Fengwei.  (2020)  Effect of Triisopropanolamine on the Compressive Strength and Early Hydration of Cement at Low Temperature.  JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION,  35  (3): (611-619).  [PMID:] [10.1007/s11595-020-2298-1]

4. Chunbao Li, Baoguo Ma, Hongbo Tan, Ting Zhang, Xiaohai Liu, Pian Chen.  (2020)  Effect of triisopropanolamine on chloride binding of cement paste with ground-granulated blast furnace slag.  CONSTRUCTION AND BUILDING MATERIALS,      [PMID:] [10.1016/j.conbuildmat.2020.119494]

5. Lei Yu, Qiao Zhang, Qi Kang, Bin Zhang, Dazhong Shen, Guizheng Zou.  (2020)  Near-Infrared Electrochemiluminescence Immunoassay with Biocompatible Au Nanoclusters as Tags.  ANALYTICAL CHEMISTRY,      [PMID:32367712] [10.1021/acs.analchem.0c00125]

6. Fubing Zou, Hongbo Tan, Xingyang He, Baoguo Ma, Xiufeng Deng, Ting Zhang, Junpeng Mei, Xiaohai Liu, Huahui Qi.  (2018)  Effect of triisopropanolamine on compressive strength and hydration of steaming-cured cement-fly ash paste.  CONSTRUCTION AND BUILDING MATERIALS,      [PMID:] [10.1016/j.conbuildmat.2018.10.087]

7. Baoguo Ma, Ting Zhang, Hongbo Tan, Xiaohai Liu, Junpeng Mei, Wenbin Jiang, Huahui Qi, Benqing Gu.  (2018)  Effect of TIPA on Chloride Immobilization in Cement-Fly Ash Paste.  Advances in Materials Science and Engineering,      [PMID:] [10.1155/2018/4179421]

8. Baoguo Ma, Ting Zhang, Hongbo Tan, Xiaohai Liu, Junpeng Mei, Huahui Qi, Wenbin Jiang, Fubing Zou.  (2018)  Effect of triisopropanolamine on compressive strength and hydration of cement-fly ash paste.  CONSTRUCTION AND BUILDING MATERIALS,      [PMID:] [10.1016/j.conbuildmat.2018.05.117]

9. Jiaqi Liu, Meiyan Hang, Minghui Jiang, Guangfei Xu, Hongbin Song.  (2024)  Corrosion inhibition performance and mechanism of triethanolamine-triisopropanolamine rust inhibitor in the simulated concrete pore solution.  Journal of Building Engineering,      [PMID:] [10.1016/j.jobe.2024.110551]

10. Guangen Zhao, Jianxiong Chen, Yongchao Xu, Cheng Peng, Qianting Wang.  (2025)  Investigation on the material removal mechanism of sapphire wafer by novel green slurry in semi-fixed abrasive polishing.  WEAR,      [PMID:] [10.1016/j.wear.2025.205762]

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12. Qingchun Xu, Xiao Liu, Pingxia Guo, Qiang Chen, Gang Liu, Meirong Cai.  (2025)  Protic Ionic Liquid Additives Achieving Multifunctional Integration of Superior Lubricity, Corrosion Resistance, and Biodegradability.  ACS Applied Engineering Materials,      [PMID:] [10.1021/acsaenm.5c00266]

13. Jiahao Li, Yuting Zhao, Jiadi Liu, Peng Li, Da An, Yi Pei, Bin Li, Xiaofeng Zheng, Yufan Feng, Hua Wu, Yanke Shan, Fei Liu.  (2025)  Novel Multifunctional Zn-MOF for Synergistic Inhibition of Coronaviruses.  ACS Applied Materials & Interfaces,      [PMID:40966063] [10.1021/acsami.5c13803]

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