≥80% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C,Protected from light,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Tris(hydroxypropyl)phosphine (THPP) is a reducing agent widely used for the reductive cleavage of disulfide bonds in small molecules in both aqueous–organic media.
Application：
Tris(hydroxypropyl)phosphine can be used:
As a reducing agent in the reduction of dehydroascorbic acid to ascorbic acid
In the cleavage of disulfide bonds in small molecules
As a catalyst in the conversion of polysulfides
| Pubchem Sid | 488197043 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488197043 |
| Canonical Smiles | C(CO)CP(CCCO)CCCO |
| IUPAC Name | 3-[bis(3-hydroxypropyl)phosphanyl]propan-1-ol |
| InChIKey | YICAEXQYKBMDNH-UHFFFAOYSA-N |
| INCHI | 1S/C9H21O3P/c10-4-1-7-13(8-2-5-11)9-3-6-12/h10-12H,1-9H2 |
| Isomeric SMILES | C(CO)CP(CCCO)CCCO |
| PubChem CID | 11006655 |
| Molecular Weight | 208.24 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organophosphorus compounds |
| Class | Organic phosphines and derivatives |
| Subclass | Not available |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Organic phosphines and derivatives |
| Alternative Parents | Primary alcohols Organopnictogen compounds Hydrocarbon derivatives |
| Molecular Framework | Aliphatic acyclic compounds |
| Substituents | Phosphine - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Primary alcohol - Organooxygen compound - Alcohol - Aliphatic acyclic compound |
| Description | This compound belongs to the class of organic compounds known as organic phosphines and derivatives. These are organic compounds containing a phosphine derivative, with the general formula B1P(R2)R3 (R1-R3=alkyl, aryl). |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 F2622477 | Certificate of Analysis | Jun 05, 2026 | T282164 |
| F2622479 | Certificate of Analysis | Jun 05, 2026 | T282164 |
| F2622481 | Certificate of Analysis | Jun 05, 2026 | T282164 |
| A2312310 | Certificate of Analysis | Oct 13, 2025 | T282164 |
| A2312311 | Certificate of Analysis | Oct 13, 2025 | T282164 |
| A2312357 | Certificate of Analysis | Oct 13, 2025 | T282164 |
| I2511682 | Certificate of Analysis | May 26, 2025 | T282164 |
| I2511684 | Certificate of Analysis | May 26, 2025 | T282164 |
| I2511685 | Certificate of Analysis | May 26, 2025 | T282164 |
| E2409446 | Certificate of Analysis | Mar 01, 2024 | T282164 |
| E2409457 | Certificate of Analysis | Mar 01, 2024 | T282164 |
| E2409487 | Certificate of Analysis | Mar 01, 2024 | T282164 |
| Sensitivity | air sensitive，Moisture sensitive， light sensitive |
|---|---|
| Molecular Weight | 208.230 g/mol |
| XLogP3 | -1.000 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 9 |
| Exact Mass | 208.123 Da |
| Monoisotopic Mass | 208.123 Da |
| Topological Polar Surface Area | 60.700 Ų |
| Heavy Atom Count | 13 |
| Formal Charge | 0 |
| Complexity | 81.800 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Mengyue Li, Junfeng Wu, Na Li, Junjian Zhou, Wen Cheng, Anhua Wu, Lianqing Liu, Niandong Jiao. (2024) Cross-Scale Drug Delivery of Diatom Microrobots Based on A Magnetic Continuum Robot for Combined Chemical and Photodynamic Therapy of Glioblastoma. ADVANCED FUNCTIONAL MATERIALS, [PMID:] [10.1002/adfm.202402333] |
| 2. Shen Xiaojing, Lv Hongying, Liu Shengnan, Yang Xiangshan, Xing Yilong, Cheng Ge, Li Juan, Zhang Rui. (2025) Porphyrin-based micro-nano assemblies combine with a well plate assay for capturing and molecular profiling of extracellular vesicles. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, [PMID:41217455] [10.1007/s00216-025-06206-2] |
| 3. Xing Yilong, Liu Shengnan, Yang Xiangshan, Li Juan, Zhang Rui. (2026) Porphyrin micro–nano assemblies for capture and isolation of extracellular vesicles. MICROCHIMICA ACTA, 193 (1): (53). [PMID:41483231] [10.1007/s00604-025-07729-2] |
