Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
224,000+ research products · Triple ISO certified · COA & SDS available for every product · Same-day shipping on in-stock items
Why this grade
Moligand™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1) , with an IC 50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders
In Vitro
VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a K d of 190 nM. VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:IC50: 150 nM (VRK1)
Specifications
Specifications & Purity
Moligand™, ≥99%
Biochemical and Physiological Mechanisms
VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1) , with an IC 50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Purity
≥99%
Names and Identifiers
| Canonical Smiles | CC1=C(C=C(C=N1)C2=CC(=C(C(=C2)F)O)F)C3=CC(=C(C(=C3)F)O)F |
|---|---|
| IUPAC Name | 4-[5-(3,5-difluoro-4-hydroxyphenyl)-6-methylpyridin-3-yl]-2,6-difluorophenol |
| InChIKey | PMRGRXLXKYUDIH-UHFFFAOYSA-N |
| INCHI | 1S/C18H11F4NO2/c1-8-12(10-5-15(21)18(25)16(22)6-10)2-11(7-23-8)9-3-13(19)17(24)14(20)4-9/h2-7,24-25H,1H3 |
| Isomeric SMILES | CC1=C(C=C(C=N1)C2=CC(=C(C(=C2)F)O)F)C3=CC(=C(C(=C3)F)O)F |
| PubChem CID | 155511407 |
| Molecular Weight | 349.28 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
3D Structure
Interactive Chemical Structure Model
Associated Targets(Human)
HeLa (62764 Activities)
VRK1 Tbio Serine/threonine-protein kinase VRK1 (258 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mechanisms of Action
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 L2412739 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412740 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412741 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412742 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412743 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412744 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412745 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412746 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412747 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412748 | Certificate of Analysis | Dec 06, 2024 | V647791 |
| L2412749 | Certificate of Analysis | Dec 06, 2024 | V647791 |
Show more ⌵
Chemical and Physical Properties
| Solubility | DMSO : 100 mg/mL (286.30 mM; Need ultrasonic) |
|---|
Solution Calculators
Reviews
Customer Reviews
Need help choosing the grade?
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
View Moligand™ grade guide →Remind me later
Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
Copyright © 2023–present Aladdin Scientific Corp. All rights reserved.