VU 0357121 - Moligand™, 10mM in DMSO , Allosteric modulator of mGlu 5 receptor, CAS No.433967-28-3, Allosteric modulator of mGlu 5 receptor

CAS: 433967-28-3 Cat. No.: V408965 Formula: C₁₇H₁₇F₂NO₂ Molecular Weight: 305.32 EC Number: 695-612-3 PubChem CID: 2296132

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

4-butoxy-N-(2,4-difluorophenyl)benzamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

VU0357121 is a novel positive allosteric modulator (PAM) ofmGlu5withEC50of 33 nM, is inactive or very weakly antagonizing at other mGlu receptor subtypes.
In vitro

VU0357121 do not bind at the MPEP allosteric site of mGlu5, thus do not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration−response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. VU0357121 show weaker cooperativity in the Ca²⁺ mobilization assay in the low-expressing HEK293A-mGlu5 cell line.

In vivo

Cell Data

cell lines：Human thyroid anaplastic carcinoma cell line, CAL-62 cell

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

4-butoxy-N-(2,4-difluorophenyl)benzamide

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

VU0357121 is a novel positive allosteric modulator (PAM) of mGlu5 with EC50 of 33 nM, is inactive or very weakly antagonizing at other mGlu receptor subtypes.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ALLOSTERIC MODULATOR

Mechanism of action

Allosteric modulator of mGlu 5 receptor

Names and Identifiers

Isomeric SMILES

CCCCOC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)F)F

WGK Germany

3

PubChem CID

2296132

Molecular Weight

305.32

Associated Targets(Human)

GRM5 Tchem Metabotropic glutamate receptor 5 (1 Activities)

Discover Target: GRM5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro

Frequently Asked Questions

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 433967-28-3, the molecular formula is C17H17F2NO2, and the molecular weight is 305.32 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.