VU 0364439 - 10mM in DMSO , CAS No.1246086-78-1

CAS: 1246086-78-1 Cat. No.: V408515 Molecular Weight: 422.29 PubChem CID: 46934289

GRADE & PURITY 10mM in DMSO

Synonyms

2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

VU 0364439 is amGlu4positive allosteric modulator (PAM), withEC50of 19.8 nM.
In vitro

In vivo

VU 0364439 possess less than ideal PK properties preventing their use as in vivo tools. It shows better stability in HLM (63% remaining) than RLM (2% remaining).
Cell Data

cell lines：HeLa, HCT116, HT29, LOVO, DU145, and NHDF cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C1=CC=C(C(=C1)NS(=O)(=O)C2=C(C=C(C=C2)NC(=O)C3=CC=CC=N3)Cl)Cl
• PubChem CID: 46934289
• Molecular Weight: 422.29

Associated Targets(Human)

GRM4 Tchem Metabotropic glutamate receptor 4 (4 Activities)

Discover Target: GRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 58 mg/mL (199.69 mM); Ethanol: 58 mg/mL (199.69 mM); Water: Insoluble