XL177A - ≥98% , CAS No.2417089-74-6

CAS: 2417089-74-6 Cat. No.: X414302 Formula: C₄₈H₅₇ClN₈O₅ Molecular Weight: 861.47 PubChem CID: 153002269

GRADE & PURITY ≥98%

Synonyms

(S)-N-(4-benzyl-5-(4-hydroxy-4-((7-(3-(4-methylpiperazin-1-yl)propanamido)-4-oxoquinazolin-3(4H)-yl)methyl)piperidin-1-yl)-5-oxopentyl)-9-chloro-5,6,7,8-tetrahydroacridine-3-carboxamide, 3-Acridinecarboxamide

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Information

XL177A is a potent, selective and irreversible inhibitor ofUbiquitin specific peptidase 7 (USP7)with IC50 of 0.34 nM.

Targets

USP7 (Cell-free assay) 0.34 nM

In vitro

Evaluation of the cellular effects of XL177A reveals that selective USP7 inhibition suppresses cancer cell growth predominantly through a p53-dependent mechanism: XL177A specifically upregulates p53 transcriptional targets transcriptome-wide, hotspot mutations in TP53 but not any other genes predict response to XL177A across a panel of ~500 cancer cell lines, and TP53 knockout rescues XL177A-mediated growth suppression of TP53 wild-type (WT) cells.

Cell Research(from reference)

Cell lines：MCF7 cells 

Concentrations：0.1 μM, 1 μM 

Incubation Time：24 h 

Specifications

Synonyms

(S)-N-(4-benzyl-5-(4-hydroxy-4-((7-(3-(4-methylpiperazin-1-yl)propanamido)-4-oxoquinazolin-3(4H)-yl)methyl)piperidin-1-yl)-5-oxopentyl)-9-chloro-5,6,7,8-tetrahydroacridine-3-carboxamide, 3-Acridinecarboxamide

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

XL177A is a potent, selective and irreversible inhibitor of Ubiquitin specific peptidase 7 (USP7) with IC50 of 0.34\u2009nM.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

Pubchem Sid

528768497

Canonical Smiles

CN1CCN(CC1)CCC(=O)NC2=CC3=C(C=C2)C(=O)N(C=N3)CC4(CCN(CC4)C(=O)C(CCCNC(=O)C5=CC6=C(C=C5)C(=C7CCCCC7=N6)Cl)CC8=CC=CC=C8)O

IUPAC Name

N-[(4S)-4-benzyl-5-[4-hydroxy-4-[[7-[3-(4-methylpiperazin-1-yl)propanoylamino]-4-oxoquinazolin-3-yl]methyl]piperidin-1-yl]-5-oxopentyl]-9-chloro-5,6,7,8-tetrahydroacridine-3-carboxamide

InChIKey

UYJWYMWIVMCGQZ-DHUJRADRSA-N

INCHI

1S/C48H57ClN8O5/c1-54-24-26-55(27-25-54)21-17-43(58)52-36-14-16-39-41(30-36)51-32-57(47(39)61)31-48(62)18-22-56(23-19-48)46(60)35(28-33-8-3-2-4-9-33)10-7-20-50-45(59)34-13-15-38-42(29-34)53-40-12-6-5-11-37(40)44(38)49/h2-4,8-9,13-16,29-30,32,35,62H,5-7,10-12,17-28,31H2,1H3,(H,50,59)(H,52,58)/t35-/m0/s1

PubChem CID

153002269

Molecular Weight

861.47

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 100 mg/mL (117.72 mM); Ethanol: 100 mg/mL (117.72 mM); Water: Insoluble