YNT 185 dihydrochloride - ≥98%(HPLC) , CAS No.1804978-82-2

CAS: 1804978-82-2 Cat. No.: Y287906 Molecular Weight: 688.66 PubChem CID: 140307520

GRADE & PURITY ≥98%(HPLC)

Synonyms

3'-[[[3-[[2-[[2-(Dimethylamino)benzoyl]amino]ethyl]amino]phenyl]amino]sulfonyl]-4'-methoxy-N,N-dimethyl-[1,1'-biphenyl]-3-carboxamide dihydrochloride

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models.

Specifications

Synonyms

3'-[[[3-[[2-[[2-(Dimethylamino)benzoyl]amino]ethyl]amino]phenyl]amino]sulfonyl]-4'-methoxy-N, N-dimethyl-[1, 1'-biphenyl]-3-carboxamide dihydrochloride

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Potent and selective orexin OX2receptor agonist (EC50= 28 nM at human OX2expressed in CHO cells). Displays approximately 100-fold selectivity for OX2over OX1(EC50= 2.75 μM at human OX1expressed in CHO cells). Depolarizes OX2-expressing histaminergic neuro

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%(HPLC)

Names and Identifiers

• Canonical Smiles: CN(C)C1=CC=CC=C1C(=O)NCCNC2=CC(=CC=C2)NS(=O)(=O)C3=C(C=CC(=C3)C4=CC(=CC=C4)C(=O)N(C)C)OC.Cl.Cl
• IUPAC Name: 2-(dimethylamino)-N-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]benzamide;dihydrochloride
• InChIKey: AIORBDHFHVKRIY-UHFFFAOYSA-N
• INCHI: 1S/C33H37N5O5S.2ClH/c1-37(2)29-15-7-6-14-28(29)32(39)35-19-18-34-26-12-9-13-27(22-26)36-44(41,42)31-21-24(16-17-30(31)43-5)23-10-8-11-25(20-23)33(40)38(3)4;;/h6-17,20-22,34,36H,18-19H2,1-5H3,(H,35,39);2*1H
• PubChem CID: 140307520
• Molecular Weight: 688.66

Chemical and Physical Properties

• Solubility: Solvent:water, Max Conc. mg/mL: 68.87, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 68.87, Max Conc. mM: 100
• Sensitivity: Moisture sensitive