Z4P - Moligand™, 10 mM in DMSO , CAS No.2361760-87-2

CAS: 2361760-87-2 Cat. No.: Z1497977 Formula: C₁₉H₂₄N₂O₂ Molecular Weight: 312.41

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Z4P is a BBB-penatrable IRE1 inhibitor with an IC 50 of 1.13 μM. Z4P in combination with Temozolomide inhibits the growth and recurrence of glioblastoma and has anti-tumor activity.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

Molecular Weight

312.41

Application Protocols

Validated application protocols are not listed for this item.

• Item-specific protocols

  • Tested applications, recommended working concentrations, and control materials: Not specified for this item; refer to CoA/Spec Sheet or internal SOPs.

• General guidance (not product-specific)

  • Prepare a fresh DMSO stock (e.g., 10–50 mM) and dilute into assay medium to the desired final concentration, keeping DMSO at the lowest workable level.
  • Include vehicle controls, concentration-response series, and orthogonal/secondary assays to confirm activity and rule out artifacts.
  • Document batch number, stock concentration, and preparation date for reproducibility.

Biological Roles

No biological role, target, or pathway information is provided for Z4P in the current product data.

• Item-specific data

  • Target/pathway: Not specified for this item; refer to CoA/Spec Sheet or product literature if available.

• General guidance (not product-specific)

  • For library compounds, determine assay interference potential (e.g., fluorescence quenching, aggregation, redox activity) using PAINS and aggregation filters; validate hits by orthogonal methods.
  • Establish compound stability in relevant buffers and in the presence of reducing agents, metals, or detergents used in assays.

Note: This product is for research use only. No medical or clinical claims are made or implied.

Buffer Applications

Buffer formulation guidance is not typically applicable to an unspecified small-molecule research compound.

• Item-specific information

  • Buffer systems and pH range: Not specified for this item; refer to CoA/Spec Sheet if any specific recommendations exist.

• Practical note

  • If preparing aqueous working solutions from DMSO stocks, choose assay buffers that maintain compound stability and solubility (e.g., HEPES or PBS at appropriate ionic strength), but the optimal buffer depends on the compound’s pKa and stability, which are unknown here.

Green Alternatives

Sustainable choices depend on the operations you perform with Z4P (e.g., dissolution, reactions, crystallization). With no structural or solvent data for this item, consider the following general, non-product-specific guidance.

• Solvent selection (general)

  • Prefer greener dipolar aprotic options where feasible (e.g., Cyrene, propylene carbonate) over DMF/NMP; for ethers, consider 2-MeTHF or CPME in place of THF/Et2O when compatible with your assay or synthesis.
  • Use ethanol or isopropanol instead of acetonitrile or dichloromethane for extraction or precipitation when technically acceptable.

• Operational practices

  • Minimize DMSO volumes in biological assays by preparing more concentrated stocks and using low final percentages.
  • Implement microscale screening to reduce solvent use; recycle and distill compatible solvents.

• Trade-offs

  • Greener solvents may alter solubility or assay background; verify compound stability and signal-to-noise before wholesale changes.

• Item-specific green alternatives

  • Not specified for this item; no direct substitutions can be recommended without knowing Z4P’s structural class and solubility profile.

Pharmaceutical Uses

No excipient or formulation roles are provided for this product, and it is designated for research use only.

• Item-specific details

  • Pharmacopeial status: Not specified for this item; refer to CoA/Spec Sheet.
  • Intended use: For research use only; not for human or veterinary applications.

• General context (not product-specific)

  • Library compounds can serve as reference materials or research standards in pre-formulation studies; any such use requires full structural and QC documentation and is outside clinical manufacturing frameworks.

No therapeutic or clinical claims are made for this product.

Physical Properties

A concise property profile supports planning for handling, solubility, and analytical methods.

• Item-specific facts (from Product Data)

  • Appearance: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.

• Literature/computed values

  • Not applicable: the structure is not provided, so no literature or computed properties can be cited.

• General property guidance for small molecules (context only; not product-specific)

  • Solubility planning: Many screening molecules are supplied as dry solids and are reconstituted in anhydrous DMSO to 10–50 mM stocks; aqueous solubility can vary widely based on polarity and ionizable groups.
  • Analytical tracking: Typical QC characterization includes LC–MS retention, HRMS, and 1H/13C NMR; UV maxima depend on chromophores.
  • Thermal behavior: Melting point and decomposition temperatures are structure-dependent; avoid assumptions and verify on the CoA.

• If you require boiling point, melting point, density, logP, pKa, refractive index, or precise solubility: Not specified for this item; refer to CoA/Spec Sheet.

Quality & Grades

Understanding the grade informs expected QC stringency and intended research use.

• Item-specific details

  • Grade/Purity: Moligand™ (as listed). Specific purity, residual solvents, water content, metal limits, and chromatographic purity are not specified for this item; refer to CoA/Spec Sheet.

• What Moligand™ implies (general description)

  • Moligand™ denotes inclusion in a small-molecule/ligand-oriented research collection designed for discovery, screening, and SAR workflows. While the exact QC panel can vary by item, such materials are typically accompanied by identity confirmation (e.g., LC–MS, NMR) and a stated purity on the CoA.

• Practical implications

  • Documentation: Request the CoA for batch-specific identity/purity metrics before bioassays or hit validation.
  • Analytics readiness: Compounds in screening collections are generally amenable to standard LC–MS and NMR; obtain recommended analytical conditions from the CoA if provided.
  • Stabilizers/additives: Not specified for this item; refer to CoA/Spec Sheet. Absence or presence of stabilizers can affect assay background.

• Research Use Note

  • For research use only. Not for human or veterinary use, medical diagnostics, or household applications.

Reaction & Applications

This product is positioned as a small molecule for research libraries; specific reactivity is not provided.

• Item-specific applications

  • Manufacturer applications: Not specified beyond inclusion in a small-molecule and compound library (category path). No particular target or reaction class is listed.

• General research applications for library members (not product-specific)

  • Screening and SAR: Use in biochemical, biophysical, or cell-based primary screening; follow with orthogonal assays and counter-screens to rule out assay interference.
  • Profiling: Evaluate stability in assay media, microsomes, or plasma as appropriate for your research; determine logD, solubility, and permeability experimentally.
  • Analytical: Establish an LC–MS/MS method for quantitation; verify purity and identity pre-assay.

• Synthetic chemistry context

  • If Z4P is required as a synthetic intermediate or reference standard, obtain structural information first. Without functional group data, guidance on named reactions or coupling strategies is not applicable.

• Practical notes

  • Prepare fresh DMSO stocks when possible to minimize hydrolysis/oxidation risk; aliquot to avoid freeze–thaw cycles.
  • If light or air sensitivity is suspected, handle under low light and inert atmosphere until properties are confirmed.

Reaction Conditions

No reaction condition guidance can be provided without knowing the functional groups present in Z4P.

• Item-specific data

  • Typical solvents, temperatures, catalysts, and yields: Not specified for this item; refer to CoA/Spec Sheet or primary literature if structural details become available.

• General considerations (not product-specific)

  • If employing Z4P in chemical reactions, perform small-scale scouting under inert atmosphere as needed, monitor by LC–MS, and establish a stability-indicating method before scale-up.

Safety & Handling

Safety details should be taken from the product-specific SDS.

• Item-specific hazard data

  • Signal word: Not specified for this item; refer to SDS.
  • H-statements: Not specified for this item; refer to SDS.
  • GHS classification and pictograms: Not specified for this item; refer to SDS.

• General laboratory precautions (non-product-specific)

  • Use in a chemical fume hood; avoid inhalation of dusts/aerosols.
  • PPE: lab coat, safety goggles, and appropriate chemically resistant gloves; consider double-gloving for DMSO stock handling due to skin permeation.
  • Incompatibilities: Unknown for this item; until confirmed, segregate from strong oxidizers, strong acids/bases, and reactive metals. Avoid moisture if the compound is moisture-sensitive.
  • First aid (overview): In case of skin/eye contact, rinse with water for 15 minutes; if inhaled, move to fresh air; if ingested, seek medical attention. Follow site-specific EHS procedures.

• Spill and waste

  • Small spills: absorb with inert material, collect in a sealable container, and dispose according to institutional and local regulations.
  • Waste: Treat as organic chemical waste; do not discharge to drains. Label with exact identity once available.

Always defer to the SDS and CoA for authoritative hazard, toxicology, and handling recommendations.

Solvent Selection

Optimal solvent choice depends on the compound’s polarity and ionization profile, which are not provided here.

• Item-specific solvent data

  • Solubility and preferred solvents: Not specified for this item; refer to CoA/Spec Sheet.

• General guidance for small-molecule libraries (not product-specific)

  • Stock preparation: Start with anhydrous DMSO to prepare a 10–50 mM stock; if insoluble, consider DMF or NMP. Filter through a 0.2 µm PTFE syringe filter if particulate is observed.
  • Aqueous working solutions: Dilute DMSO stocks into aqueous buffers keeping final DMSO ≤0.1–1% v/v for cell-free assays and ≤0.1–0.5% v/v for many cell-based assays, as tolerated.
  • Alternative media: For hydrophobic compounds, co-solvents (DMSO:EtOH:buffer blends) or cyclodextrin formulations may assist; for zwitterions/bases/acids, adjust pH relative to pKa for solubilization (pKa not available for this item).

• Comparison note

  • Without structural data, polarity class, dielectric constant, and miscibility profile are unknown. Confirm solubility experimentally and consult the CoA.

Storage & Reconstitution

Proper storage preserves integrity for reproducible results.

• Item-specific facts (from Product Data)

  • Storage conditions: Store at -80°C.
  • Shipped in: Dry ice packs + Cold packs.
  • Appearance: Not specified for this item; refer to CoA/Spec Sheet.
  • Reconstitution solvent and concentration: Not specified for this item; refer to CoA/Spec Sheet.

• Practical handling guidance (general; not product-specific)

  • Upon receipt: Keep at -80°C. Allow vials to equilibrate to room temperature in a desiccated environment before opening to avoid condensation.
  • Aliquoting: If solid, quickly weigh and aliquot under dry conditions; if solution, aliquot into low-adsorption tubes to minimize freeze–thaw cycles.
  • Reconstitution: Common practice for small molecules is to dissolve in anhydrous DMSO to 10–50 mM; if needed, consider DMF or ethanol. Verify clarity and homogeneity; filter through 0.2 µm PTFE if particulates are present.
  • Stability: Unknown for this item. Protect from light and moisture until stability is established. Avoid repeated freeze–thaw; store working DMSO stocks at -20°C or -80°C as stability permits.

• Documentation

  • Record batch/lot, preparation date, solvent, and concentration. For definitive storage lifetime and re-test intervals, consult the CoA/Spec Sheet.

Structure & Identity

Brief overview: Z4P is listed as a small-molecule library member; structural identifiers are not provided in the current product data.

• Item-specific facts (from Product Data)

  • Product name: Z4P (SKU: Z1497977)
  • CAS: 2361760-87-2
  • Grade: Moligand™
  • Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
  • SMILES: Not specified for this item; refer to CoA/Spec Sheet.
  • InChIKey: Not specified for this item; refer to CoA/Spec Sheet.

• Structural features

  • Not specified for this item; refer to CoA/Spec Sheet for functional groups, ring systems, or stereochemistry if available.

• 2D structure (verbal description)

  • Not available. Without SMILES/InChIKey or a structure image, the 2D connectivity and functional group layout cannot be described. Please consult the CoA/Spec Sheet or contact Technical Support for structural details.

Synthetic Utility

Without structural information, it is not possible to describe functional group reactivity or position Z4P within specific synthetic transformations.

• Item-specific information

  • Functional groups and protecting strategies: Not specified for this item; refer to CoA/Spec Sheet.

• General advice (not product-specific)

  • If the compound is used as a reference standard or intermediate, obtain the full structure, purity, and impurity profile to plan compatible reaction conditions and workups.
  • Confirm stability against acids/bases, nucleophiles, oxidants, and reductants before integrating into multistep sequences.

Target Specificity

Target specificity information (e.g., biochemical targets, receptors, enzymes) is not provided for Z4P.

• Item-specific data
  • Target(s), affinity, selectivity: Not specified for this item; refer to CoA/Spec Sheet or supplementary product literature if available.

This section is typically applicable for bioactive ligands; in the absence of target data, please consult your screening results and confirmatory assays.

Frequently Asked Questions

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2361760-87-2, the molecular formula is C19H24N2O2, and the molecular weight is 312.41 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.