ZAP 180013 - ≥98%(HPLC) , CAS No.873080-25-2

CAS: 873080-25-2 Cat. No.: Z288682 Molecular Weight: 454.32 PubChem CID: 2988718

GRADE & PURITY ≥98%(HPLC)

Synonyms

5-Chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-4-pyrimidinecarboxamide

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Product description

ZAP-180013 is a zeta-chain-associated protein kinase 70 (ZAP-70) inhibitor with an IC50 of 1.8 μM. ZAP-180013 inhibits the interaction of ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs).

Specifications

Synonyms

5-Chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-4-pyrimidinecarboxamide

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Zeta-chain-associated protein kinase 70 (Zap70) inhibitor (IC50= 1.8 μM in fluorescence polarization assay). Inhibits the interaction of Zap70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs), within the T-cell antigen receptor (TCR)

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%(HPLC)

Names and Identifiers

• Canonical Smiles: CCS(=O)(=O)C1=NC=C(C(=N1)C(=O)N(CC2=CC=C(C=C2)Cl)CC3=CC=CO3)Cl
• IUPAC Name: 5-chloro-N-[(4-chlorophenyl)methyl]-2-ethylsulfonyl-N-(furan-2-ylmethyl)pyrimidine-4-carboxamide
• InChIKey: GTWKIPDKVRLUKN-UHFFFAOYSA-N
• INCHI: 1S/C19H17Cl2N3O4S/c1-2-29(26,27)19-22-10-16(21)17(23-19)18(25)24(12-15-4-3-9-28-15)11-13-5-7-14(20)8-6-13/h3-10H,2,11-12H2,1H3
• PubChem CID: 2988718
• Molecular Weight: 454.32

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 45.43, Max Conc. mM: 100