Aducanumab (anti-APP) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to APP, >95%, Human IgG1, BINDING AGENT of Beta amyloid A4 protein binding agent, BINDING AGENT of Beta amyloid A4 protein binding agent

CAS: 1384260-65-4 Cat. No.: Ab170476

GRADE & PURITY Animal Free, Carrier Free, Recombinant, Validated, ExactAb™, Low Endotoxin, Azide Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Human

Reactive species

Cynomolgus monkey, Human, Mouse

Isotype

Human IgG1

Conjugation

Unconjugated

Descripción general

Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated

Specifications

Product Name

Aducanumab (anti-APP) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to APP, >95%, Human IgG1, BINDING AGENT of Beta amyloid A4 protein binding agent

Sinónimos

Aducanumab | A4_HUMAN antibody | AAA antibody | ABETA antibody | ABPP antibody | AD1 antibody | AICD-50 antibody | AICD-57 antibody | AICD-59 antibody | AID(50) antibody | AID(57) antibody | AID(59) antibody | Alzheimer disease amyloid protein antibody |

Especificaciones y pureza

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Especies hospedadoras

Human

Especificidad

APP

Aplicación

ELISA, Functional Assay, Flow cytometry, Kinetics (BLI), Kinetics (SPR)

Conjugación

Unconjugated

Grado

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Tipo de acción

BINDING AGENT

Mecanismo de acción

BINDING AGENT of Beta amyloid A4 protein binding agent

Tipo de anticuerpo

Primary antibody

Clonalidad

Recombinant

Isotipo

Human IgG1

Tipo de cadena ligera

kappa

SDS-PAGE

26.6 kDa (Light Chain) & 52.7 kDa (Heavy Chain), under reducing conditions; 181.7 kDa, under non-reducing conditions.

Método de purificación

Protein A purified

Pureza

>95%

Fuente

CHO supernatant

Concentración

See COA

CAS

1384260-65-4

Almacenamiento y envío

Forma

Liquid

Condiciones de almacenamiento de almacenamiento

Store at -80°C,Avoid repeated freezing and thawing

Enviado en

Dry ice packs + Cold packs

Estabilidad y almacenamiento

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Imágenes

Flow Cytometry: Aducanumab (anti-APP) (Ab170476)

Aducanumab (anti-APP) (Ab170476) - Flow Cytometry
Flow Cytometry analysis of HUVEC cells labelling APP (red) with Aducanumab (anti-APP) (Ab170476). The cells were fixed and permeabilized with methanol (5 min). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Aducanumab (anti-APP) (Ab170476)

Aducanumab (anti-APP) (Ab170476) - SEC
The purity of Aducanumab (anti-APP) (Ab170476) is more than 95% verified by HPLC.

Objetivos asociados (humanos)

APP Tclin Amyloid-beta A4 protein (0 Activities)

Discover Target: APP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mecanismos de acción

Referencias

1. Xiaoming Zha, Doriano Lamba, Lili Zhang, Yinghan Lou, Changxu Xu, Di Kang, Li Chen, Yungen Xu, Luyong Zhang, Angela De Simone, Sarah Samez, Alessandro Pesaresi, Jure Stojan, Manuela G. Lopez, Javier Egea, Vincenza Andrisano, Manuela Bartolini.  (2015)  Novel Tacrine–Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:26632651] [10.1021/acs.jmedchem.5b01119]