Crovalimab (anti-Complement C5) - Primary antibody, specific to C5, Human IgG1, INHIBITOR of Complement C5 inhibitor, INHIBITOR of Complement C5 inhibitor

CAS: 1917321-26-6 Cat. No.: Ab182862
Disponible para pedir
CALIDAD & PUREZA Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ≥95%(SDS-PAGE&SEC-HPLC) See COA
Application
Animal Model, ELISA, Flow Cytometry, Functional Assay
Host species
Human
Reactive species
Human
Isotype
Human IgG1
Conjugation
Unconjugated
★
Talla
USA
Alemania (EU)*
Precio
Cantidad
100μg
Ab182862-100μg
Disponible ≥10
—
115,90US$
1mg
Ab182862-1mg
4 Disponible
—
571,90US$
5mg
Ab182862-5mg
1 Disponible
—
1.499,90US$
10mg
Ab182862-10mg
Fabricado bajo pedido en EE. UU. · 2–4 semanas ·
—
2.399,90US$
Enter a quantity for the sizes you want to add.
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Por qué esta calidad

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA Animal Free,Azide Free,Carrier Free,ExactAb™,Low Endotoxin,Recombinant,Validated para flujos de trabajo cromatográficos y analíticos sensibles que requieren una interferencia mínima de la línea base.

🌡

Almacenamiento y envío

Store at -80°C,Avoid repeated freezing and thawing Envío Dry ice packs + Cold packs. Consulte el COA específico del lote para conocer las especificaciones exactas.

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Documentos de calidad

SDS, COA, ficha técnica y hoja de especificaciones disponibles para descargar. COA específico del lote accesible mediante búsqueda por número de lote.

📚

Prueba documental

Citado en 0 publicaciones revisadas por pares sobre cromatografía, síntesis orgánica y reacciones de acoplamiento cruzado.

Descripción general

Crovalimab (anti-Complement C5) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab (anti-Complement C5) binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab (anti-Complement C5) can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab (anti-Complement C5) inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab (anti-Complement C5) has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Especificaciones

Product Name
Crovalimab (anti-Complement C5) - Primary antibody, specific to C5, Human IgG1, INHIBITOR of Complement C5 inhibitor
Sinónimos
Anaphylatoxin C5a analog antibody | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 antibody | C5 antibody | C5a anaphylatoxin antibody | C5a antibody | C5b antibody | CO5_HUMAN antibody | Complement C5 alpha'' chain antibody | Complemen
Especificaciones y pureza
Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Especies hospedadoras
Human
Especificidad
C5
Conjugación
Unconjugated
Grado
Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Tipo de acción
INHIBITOR
Mecanismo de acción
INHIBITOR of Complement C5 inhibitor
Isotipo
Human IgG1
Tipo de cadena ligera
kappa
SDS-PAGE
26.4 kDa (Light Chain) & 52.7 kDa (Heavy Chain), under reducing conditions; 190.6 kDa, under non-reducing conditions.
Método de purificación
Protein A purified
Concentración
See COA
CAS
1917321-26-6
Product Line
Productos biológicos
Almacenamiento y envío
Forma
Liquid
Condiciones de almacenamiento de almacenamiento
Store at -80°C,Avoid repeated freezing and thawing
Enviado en
Dry ice packs + Cold packs
Estabilidad y almacenamiento
Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
Imágenes

Crovalimab (anti-Complement C5) (Ab182862) - ELISA
Immobilized Human Complement C5 Protein at 2.0 μg/mL can bind Crovalimab (anti-Complement C5) (Ab182862) with the EC50 of 9.58 ng/mL.

Crovalimab (anti-Complement C5) (Ab182862) - SEC
The purity of Crovalimab (anti-Complement C5) (Ab182862) is more than 95% verified by HPLC.

Documentación

📋 Hoja de datos de seguridad (SDS)

Documento completo sobre peligros, manipulación, almacenamiento y cumplimiento normativo.

<<<<<<< HEAD Descargar SDS → ======= Descargar SDS → >>>>>>> release248-p3

✅ Certificado de análisis (COA)

Datos de calidad específicos del lote. Introduzca su número de lote para obtener el COA exacto.

Buscar COA →

📊 Ficha técnica

Resumen de referencia rápida de las especificaciones y aplicaciones del producto.

Ver ficha técnica →

🔬 Hoja de especificaciones

Atributos de calidad completos y criterios de aceptación para esta calidad.

Ver hoja de especificaciones →

Datos avanzados

Objetivos asociados (humanos)
C5 Tclin Complement C5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot NumberCertificate TypeFechaArticulo
ZJ24F0606987ZJ24F0606987Certificate of AnalysisApr 16, 2026 Ab182862
ZJ24F0606988ZJ24F0606988Certificate of AnalysisApr 16, 2026 Ab182862
ZJ24F0606989ZJ24F0606989Certificate of AnalysisApr 16, 2026 Ab182862
ZJ26F0433780ZJ26F0433780Certificate of AnalysisApr 03, 2026 Ab182862
ZJ26F0433779ZJ26F0433779Certificate of AnalysisApr 03, 2026 Ab182862
ZJ26F0433778ZJ26F0433778Certificate of AnalysisApr 03, 2026 Ab182862
ZJ25F0927252ZJ25F0927252Certificate of AnalysisSep 16, 2025 Ab182862
ZJ25F0927251ZJ25F0927251Certificate of AnalysisSep 16, 2025 Ab182862
ZJ25F0927250ZJ25F0927250Certificate of AnalysisSep 16, 2025 Ab182862
Preguntas frecuentes y artículos
Calculadoras de soluciones
Reseñas

Reseñas de cliente

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