Antibody-drug conjugate (ADC) is an effective combination of chemotherapy and immunotherapy. The concept was first proposed more than 100 years ago by German scientist Paul Ehrlich. He likens ADCs to "wonder drugs" because they can clearly identify targets (cancer cells) without harming the ...
It is a long-term goal for biomedical researchers to develop efficient and reliable methods to make accurate and targeted changes in the genome of living cells. In recent years, a new tool based on bacterial CRISPR-associated protein-9 nuclease (Cas9) from Streptococcus pyogenes has aroused ...
In the field of tissue engineering and regenerative medicine, the design of biomaterial scaffolds that can reproduce the complex extracellular nature of living tissues in three dimensions is a challenging requirement. Hydrogels are a widely studied and developed class of synthetic extracellular ...
The Janus kinase (JAK) signal transduction and transcriptional activator (STAT) pathway plays a key role in the signaling of a large number of cytokines and growth factors. These cytokines and growth factors are responsible for a variety of cellular functions, including proliferation, growth, ...
Trifluoromethyl is one of the important chemical groups in the field of medicinal chemistry, and is widely used in bioactive molecules because of its high lipid solubility, excellent metabolic stability, high electronegativity and good bioavailability. The introduction of trifluoromethyl in drug ...
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