Narsoplimab (anti-MASP2) - Primary antibody, specific to MASP2, >95%, Human IgG4SP, INHIBITOR of Mannan-binding lectin serine protease 2 inhibitor, INHIBITOR of Mannan-binding lectin serine protease 2 inhibitor

CAS: 2108782-45-0 Cat. No.: Ab176557

GRADE & PURITY Animal Free, Carrier Free, Recombinant, Validated, ExactAb™, Low Endotoxin, Azide Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Human

Reactive species

Cynomolgus monkey, Human, Mouse, Rat, Rhesus monkey

Isotype

Human IgG4SP

Conjugation

Unconjugated

Descripción general

Narsoplimab (anti-MASP2) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab (anti-MASP2) can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Specifications

Product Name

Narsoplimab (anti-MASP2) - Primary antibody, specific to MASP2, >95%, Human IgG4SP, INHIBITOR of Mannan-binding lectin serine protease 2 inhibitor

Sinónimos

Mannan binding lectin serine peptidase 2 antibody | Mannan binding lectin serine protease 2 antibody | Mannose binding protein associated serine protease 2 antibody | MAP 19 antibody | MAP19 antibody | MASP 2 antibody | MBL associated plasma protein of 19

Especificaciones y pureza

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Especies hospedadoras

Human

Especificidad

MASP2

Conjugación

Unconjugated

Grado

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Tipo de acción

INHIBITOR

Mecanismo de acción

INHIBITOR of Mannan-binding lectin serine protease 2 inhibitor

Isotipo

Human IgG4SP

Tipo de cadena ligera

lambdaC2

SDS-PAGE

28.3 kDa (Light Chain) & 51.6 kDa (Heavy Chain), under reducing conditions; 178.5 kDa, under non-reducing conditions.

Método de purificación

Protein A purified

Pureza

>95%

Concentración

See COA

CAS

2108782-45-0

Almacenamiento y envío

Forma

Liquid

Condiciones de almacenamiento de almacenamiento

Store at -80°C,Avoid repeated freezing and thawing

Enviado en

Dry ice packs + Cold packs

Estabilidad y almacenamiento

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Imágenes

SEC: Narsoplimab (anti-MASP2) (Ab176557)

Narsoplimab (anti-MASP2) (Ab176557) - SEC
The purity of Narsoplimab (anti-MASP2) (Ab176557) is more than 95% verified by HPLC.

ELISA: Narsoplimab (anti-MASP2) (Ab176557)

Narsoplimab (anti-MASP2) (Ab176557) - ELISA
Immobilized huMASP-2A-chis at 2 μg/mL can bind Narsoplimab (anti-MASP2) (Ab176557) with the EC₅₀ of 6.3 ng/mL.

Objetivos asociados (humanos)

MASP2 Tchem Mannan-binding lectin serine protease 2 (0 Activities)

Discover Target: MASP2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mecanismos de acción

Referencias

1. Jing Xie, Mengqi Wu, Zhijun Zhou, Yuan Liu, Xiaohua Liu, Kaijuan Wu, Dongqian Yang, Yixiao Wang, Kang Liu, Chandara Ngim, Zheng Wang, Liping Jiang.  (2026)  The resistance to Toxoplasma gondii in Microtus fortis is associated with the activation of the complement lectin pathway.  PLoS Neglected Tropical Diseases,  20  (3): (e0014052).  [PMID:41770731] [10.1371/journal.pntd.0014052]