Resomelagon acetate , CAS No.1809420-72-1

CAS: 1809420-72-1 Cat. No.: R647324 Molecular Weight: 358.35

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

Resomelagon (AP1189) acetate is a potent, orally active melanocortin receptor (MR) agonist about MC 1 and MC 3 . Resomelagon acetate induces ERK1/2 phosphorylation and Ca 2+ mobilization. Resomelagon acetate has anti-inflammatory activity. Resomelagon acetate can be used for obesity and chronic inflammation research

In Vitro

Resomelagon acetate (0-1000 μM; 8 min; HEK293A cells) promotes melanocortin signal transduction through ERK1/2 phosphorylation and Ca 2+ mobilization. Resomelagon acetate (1 nM; 30 min; peritoneal macrophages) has anti-inflammatory activity and inhibits TNF-α release and efferocytosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Resomelagon acetate (0-10 mg/kg; i.p., i.v. and p.o.; for 24 h; male C57BL/6J wild-type (WT) and BALB/c mice) promotes resolution of acute inflammation in vivo . Resomelagon acetate (25-50 mg/kg; p.o.; daily, for 8 d; male C57BL/6J wild-type (WT) and BALB/c mice) reduces arthritis in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Targrt: MC1 and MC3

Specifications

Biochemical and Physiological Mechanisms

Resomelagon (AP1189) acetate is a potent, orally active melanocortin receptor (MR) agonist about MC 1 and MC 3 . Resomelagon acetate induces ERK1/2 phosphorylation and Ca 2+ mobilization. Resomelagon acetate has anti-inflammatory activity. Resomelagon ace

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: N=C(N)N/N=C/C=C/C1=CC=CN1C2=C(C=CC=C2)[N+]([O-])=O.CC(O)=O
• Molecular Weight: 358.35