Rifamycin sodium salt - ≥98% , CAS No.14897-39-3

CAS: 14897-39-3 Cat. No.: R189026 Molecular Weight: 719.75 EC Number: 238-965-7 PubChem CID: 23702994

GRADE & PURITY ≥98%

Synonyms

2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate, monosodium salt | EINECS 238-965-7 | Rifamycin, monosodium salt | Otofa | RIFAMYCIN SODIUM [ORANG

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Product Describtion:

Rifamycin sodium is an antibacterial drug used for treatment of mycobacterium infections.

Specifications

Synonyms

2, 7-(Epoxypentadeca(1, 11, 13)trienimino)naphtho(2, 1-b)furan-1, 11(2H)-dione, 5, 6, 9, 17, 19, 21-hexahydroxy-23-methoxy-2, 4, 12, 16, 18, 20, 22-heptamethyl-, 21-acetate, monosodium salt | EINECS 238-965-7 | Rifamycin, monosodium salt | Otofa | RIFAMYCIN SODIUM [ORANG

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Specific bacterial DNA-dependent RNA polymerase binding inhibitor. Prevents initiation of RNA synthesis. Anti-inflammatory and antimicrobial agent. Active in vivo and in vitro .

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CC1C=CC=C(C(=O)NC2=CC(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)[O-])C.[Na+]
• IUPAC Name: sodium;(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-13-acetyloxy-2,15,17,29-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-27-olate
• InChIKey: YVOFSHPIJOYKSH-NLYBMVFSSA-M
• INCHI: 1S/C37H47NO12.Na/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41;/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46);/q;+1/p-1/b11-10+,14-13+,17-12-;/t16-,18+,19+,20+,25-,29-,30+,33+,37-;/m0./s1
• Isomeric SMILES: C[C@H]1/C=C/C=C(\C(=O)NC2=CC(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)[O-])/C.[Na+]
• PubChem CID: 23702994
• Molecular Weight: 719.75

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Class Macrolactams

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Class: Macrolactams
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Macrolactams
• Alternative Parents: Naphthofurans Naphthols and derivatives Benzofurans Coumarans Aryl alkyl ketones Phenoxides Ketals Secondary carboxylic acid amides Secondary alcohols Carboxylic acid esters Lactams Polyols Azacyclic compounds Oxacyclic compounds Dialkyl ethers Monocarboxylic acids and derivatives Organopnictogen compounds Hydrocarbon derivatives Organic zwitterions Organic sodium salts Organonitrogen compounds Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Macrolactam - Naphthofuran - 1-naphthol - Naphthalene - Benzofuran - Coumaran - Aryl ketone - Aryl alkyl ketone - Ketal - Phenoxide - Benzenoid - Lactam - Secondary alcohol - Ketone - Carboxylic acid ester - Carboxamide group - Secondary carboxylic acid amide - Acetal - Carboxylic acid derivative - Dialkyl ether - Ether - Oxacycle - Monocarboxylic acid or derivatives - Azacycle - Organic alkali metal salt - Organoheterocyclic compound - Polyol - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Alcohol - Organopnictogen compound - Organic sodium salt - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Organic salt - Organic zwitterion - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as macrolactams. These are cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. They are nitrogen analogues (the a nitrogen atom replacing the o atom of the cyclic carboxylic acid group ) of the naturally occurring macrolides.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in water, alcohol and dimethyl sulfoxide
• Sensitivity: Air sensitive;Light sensitive;Moisture sensitive
• Molecular Weight: 719.700 g/mol
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 3
• Exact Mass: 719.292 Da
• Monoisotopic Mass: 719.292 Da
• Topological Polar Surface Area: 204.000 Ų
• Heavy Atom Count: 51
• Formal Charge: 0
• Complexity: 1340.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 9
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 3
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 3
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Fang-Zhu Wu, Feng-Li Yu, Bing Yuan, Cong-Xia Xie, Shi-Tao Yu.  (2019)  Highly selective and recyclable hydrogenation of α-pinene catalyzed by ruthenium nanoparticles loaded on amphiphilic core–shell magnetic nanomaterials.  APPLIED ORGANOMETALLIC CHEMISTRY,  33  (10): (e5165).  [PMID:] [10.1002/aoc.5165]

2. Liufu Zhang, Jianwei Di, Haoyang Wang, Zhiwei Zhou, Yuxi Wang, Jun Long, Yanqiu Zhang, Jing Guo, Xu Jiang, Lu Shao.  (2025)  Tear-film-inspired interfacial polymerization engineering nanofiltration membrane architecture for highly efficient antibiotic desalination.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.164990]