Stattic - 10mM in DMSO , CAS No.19983-44-9

CAS: 19983-44-9 Cat. No.: S407764 Peso molecular: 211.19 Número EC: 633-746-6 PubChem CID: 2779853

GRADE & PURITY 10mM in DMSO

Synonyms

Benzo[b]thiophene, 6-nitro-, 1,1-dioxide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Stattic, the first nonpeptidic small molecule, potently inhibitsSTAT3activation and nuclear translocation withIC50of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic inducesapoptosis.
In vitro

Stattic inhibits binding of a phosphotyrosine-containing peptide derived from the gp130 receptor to the STAT3 SH2 domain in a strongly temperature-dependent manner. Stattic only has a very weak effect on binding of a tyrosinephosphorylated peptide to the SH2-domain of the tyrosine kinase Lck. And it doesn’t inhibit dimerization of two other dimeric transcription factors (c-Myc/Max and Jun/Jun). It also inhibits fluorescein-labeled phosphopeptides to the SH2 domains of STAT1 and STAT5b. Stattic selectively inhibits DNA binding of STAT3 homodimers at a concentration of 10 μM. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells). Stattic increases the apoptotic rate of STAT3-dependent breast cancer cell lines.

In vivo

Cell Data

cell lines：COS1, Hepa or SH-SY5Y cells

Concentrations：~2.5 μM

Incubation Time：48 h

Powder Purity:≥98%

Specifications

Sinónimos

Benzo[b]thiophene, 6-nitro-, 1, 1-dioxide

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic induces apoptosis.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nombres e identificadores

• Isómeros SMILES: C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
• WGK Alemania: 3
• PubChem CID: 2779853
• Peso molecular: 211.19

Objetivos asociados (humanos)

HIF1A Tchem Hypoxia-inducible factor 1-alpha (1 Activities)

Discover Target: HIF1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 12.5 mg/mL (40.15 mM)
• Índice de refracción: 1.67
• Punto de ebullición (°C): 461.1° C
• Punto de fusión (°C): 186 - 188 °C