1-Methyl-D-tryptophan - Moligand™, ≥96% , mTORC1 activator, CAS No.110117-83-4, mTORC1 activator

CAS: 110117-83-4 Cat. No.: M115830 Molecular Weight: 218.25
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥96%
Synonyms
AKOS015850753 | Indoximod (NLG-8189) | AKOS015898463 | D-1-methyltryptophan | NCGC00346842-01 | NSC721782 | NSC-721782 | SMP2_000028 | A14397 | CCG-266709 | D10640 | AMY22762 | D-Trp(Me)-OH | Indoximod (USAN/INN) | ZADWXFSZEAPBJS-SNVBAGLBSA-N | A822528 |
Storage
Room temperature
Shipped In
Normal
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
250mg
M115830-250mg
3
$58.90
1g
M115830-1g
3
$212.90
5g
M115830-5g
2

$527.90

$955.90
Save $428.00 (44.77%)
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Why this grade

Moligand™, ≥96% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 8 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
AKOS015850753 | Indoximod (NLG-8189) | AKOS015898463 | D-1-methyltryptophan | NCGC00346842-01 | NSC721782 | NSC-721782 | SMP2_000028 | A14397 | CCG-266709 | D10640 | AMY22762 | D-Trp(Me)-OH | Indoximod (USAN/INN) | ZADWXFSZEAPBJS-SNVBAGLBSA-N | A822528 |
Specifications & Purity
Moligand™, ≥96%
Biochemical and Physiological Mechanisms
Methylated tryptophan which acts as an Indoleamine 2, 3-dioxygenase (IDO) inhibitor. Prevents T-cell anergy triggered by dendritic cells overexpressing IDO in mice.
Storage
Room temperature
Shipped In
Normal
Grade
Moligand™
Action Type
ACTIVATOR
Mechanism of action
mTORC1 activator
Purity
≥96%
Product Properties
ALogP-1.3
Names and Identifiers
Pubchem Sid488189681
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488189681
Canonical SmilesCN1C=C(C2=CC=CC=C21)CC(C(=O)O)N
IUPAC Name(2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid
InChIKeyZADWXFSZEAPBJS-SNVBAGLBSA-N
INCHI1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m1/s1
Isomeric SMILES CN1C=C(C2=CC=CC=C21)C[C@H](C(=O)O)N
WGK Germany 3
Molecular Weight 218.25
Reaxy-Rn 20071
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20071&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassIndoles and derivatives
SubclassIndolyl carboxylic acids and derivatives
Intermediate Tree Nodes Not available
Direct ParentIndolyl carboxylic acids and derivatives
Alternative Parents 3-alkylindoles  D-alpha-amino acids  N-alkylindoles  Aralkylamines  Benzenoids  N-methylpyrroles  Heteroaromatic compounds  Amino acids  Carboxylic acids  Azacyclic compounds  Monocarboxylic acids and derivatives  Hydrocarbon derivatives  Carbonyl compounds  Organopnictogen compounds  Organic oxides  Monoalkylamines  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Indolyl carboxylic acid derivative - Alpha-amino acid - Alpha-amino acid or derivatives - N-alkylindole - D-alpha-amino acid - 3-alkylindole - Indole - Aralkylamine - N-methylpyrrole - Benzenoid - Substituted pyrrole - Heteroaromatic compound - Pyrrole - Amino acid or derivatives - Amino acid - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Azacycle - Amine - Primary aliphatic amine - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Primary amine - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as indolyl carboxylic acids and derivatives. These are compounds containing a carboxylic acid chain (of at least 2 carbon atoms) linked to an indole ring.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
A498 (42825 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHN (49357 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAKI-1 (44928 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCRF-CEM (65223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COLO 205 (50209 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-145 (51482 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KM12 (47707 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
M14 (47487 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MOLT-4 (49676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-3 (48710 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-4 (44535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-5 (45555 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-8 (47708 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPMI-8226 (44974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RXF 393 (41971 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SF-295 (48000 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-2 (46422 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-28 (48833 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-OV-3 (52876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SN12C (47755 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SNB-19 (46794 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TK-10 (45540 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-251 (51189 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UACC-257 (46019 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UACC-62 (47335 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UO-31 (46270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
786-0 (47912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI/ADR-RES (33767 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
T47D (39041 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EKVX (44102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H322M (45589 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCC 2998 (41480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H460 (60772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SF-268 (49410 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HUVEC (11049 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IGROV-1 (47897 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LOX IMVI (44321 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HOP-62 (47048 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-435 (38290 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-N (28205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Malme-3M (44254 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ido2 Indoleamine 2,3-dioxygenase 2 (105 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeDateItem
E2227449Certificate of AnalysisMar 11, 2026 M115830
E2227451Certificate of AnalysisMar 11, 2026 M115830
E2227463Certificate of AnalysisMar 11, 2026 M115830
I2526058Certificate of AnalysisOct 10, 2025 M115830
G2028027Certificate of AnalysisMay 08, 2024 M115830
G2028026Certificate of AnalysisMay 08, 2024 M115830
C1922017Certificate of AnalysisJan 20, 2023 M115830
H2508809Certificate of AnalysisMar 12, 2022 M115830
Chemical and Physical Properties
Melt Point(°C)242-245°C
Molecular Weight218.250 g/mol
XLogP3-1.300
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass218.106 Da
Monoisotopic Mass218.106 Da
Topological Polar Surface Area68.300 Ų
Heavy Atom Count16
Formal Charge0
Complexity270.000
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Xinpei Liu, Xuan Yi, Jingyu Gu, Zhongfang Ji, Minqian Zhu, Mengling Shen, Yuanyuan Ren, Li Guo, Teng Liu, Nan Ding, Kai Yang.  (2023)  Immunoregulatory liposomes hitchhiking on neutrophils for enhanced carbon ion radiotherapy-assisted immunotherapy of glioblastoma.  Nano Today,      [PMID:] [10.1016/j.nantod.2023.102037]
2. Shikai Zhang, Qing Xu, Changbo Ji, Xiaoyu Han, Yang Zhou, Chao Liang, Linran Ma, Weijian Sun, Yanling Li, Zhengyou Yang, Fengchun Zhao, Yuan Tian.  (2023)  Study on secondary metabolites of endophytic fungus Diaporthe sp. AC1 induced by tryptophan analogs.  Frontiers in Microbiology,      [PMID:37876783] [10.3389/fmicb.2023.1254609]
3. Ping Huang, Yao Yang, Wenyan Wang, Zimu Li, Nansha Gao, Hongzhong Chen, Xiaowei Zeng.  (2023)  Self-driven nanoprodrug platform with enhanced ferroptosis for synergistic photothermal-IDO immunotherapy.  BIOMATERIALS,      [PMID:37196407] [10.1016/j.biomaterials.2023.122157]
4. Li Xiangfei, Qiao Juan, Sun Yongjun, Li Zhiwei, Qi Li.  (2021)  Ligand-modulated synthesis of gold nanoclusters for sensitive and selective detection of folic acid.  Journal of Analytical Science and Technology,  12  (1): (1-8).  [PMID:] [10.1186/s40543-021-00266-6]
5. Qilin Li, Jia Liu, Huiling Fan, Lin Shi, Yan Deng, Lei Zhao, Mengxi Xiang, Yunruo Xu, Xulin Jiang, Guobin Wang, Lin Wang, Zheng Wang.  (2020)  IDO-inhibitor potentiated immunogenic chemotherapy abolishes primary tumor growth and eradicates metastatic lesions by targeting distinct compartments within tumor microenvironment.  BIOMATERIALS,      [PMID:33172606] [10.1016/j.biomaterials.2020.120388]
6. Wenshuai Li, Saipeng Huang, Huiyun Wen, Yane Luo, Jiewei Cheng, Zhao Jia, Pu Han, Weiming Xue.  (2019)  Pyridine functionalized carbon dots for specific detection of tryptophan in human serum samples and living cells.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2019.104579]
7. Li Liao, Yufei Liu, Xianhai Li, Zewei Jiang, Zhijie Jiang, Jing Yao.  (2025)  Dual-Regulated Biomimetic Nanocomposites For Promoted Tumor Photodynamic Immunotherapy.  ACS Applied Materials & Interfaces,      [PMID:40159083] [10.1021/acsami.5c00763]
8. Xiaorong Kou, Xue Wu, Tao He, Liping Bai, Xinchao Li, Rui Luo, Yangsong Xu, Yixi Wang, Meiling Shen, Changyang Gong, Qinjie Wu.  (2026)  Tumor-activated dual metabolic nanomodulator turns over tolerogenic tumor control and unleashes systemic immune responses.  JOURNAL OF NANOBIOTECHNOLOGY,      [PMID:41629977] [10.1186/s12951-026-04086-x]
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