2-(2-Hydroxy-5-methylphenyl)benzotriazole - ≥99% , CAS No.2440-22-4

CAS: 2440-22-4 Cat. No.: H157228 Molecular Weight: 225.25 EC Number: 219-470-5
AVAILABLE TO ORDER
GRADE & PURITY ≥99%
Synonyms
DROMETRIZOLE [USAN] | DTXCID207479 | NSC91885 | NCGC00166243-03 | UV-P | NCIOpen2_005624 | AS-12550 | DROMETRIZOLE [INN] | Ultraviolet Absorbent UV-P | Drometrizole | HMS2650F14 | MLS000713327 | NCGC00166243-02 | STK096143 | 2-(2H-1,2,3-Benzotriazol-2-yl)
Storage
Room temperature
Shipped In
Normal
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
25g
H157228-25g
≥10

$9.90

$14.90
Save $5.00 (33.56%)
100g
H157228-100g
2

$11.90

$17.90
Save $6.00 (33.52%)
250g
H157228-250g
1

$26.90

$40.90
Save $14.00 (34.23%)
500g
H157228-500g
2

$48.90

$73.90
Save $25.00 (33.83%)
Enter a quantity for the sizes you want to add.
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Why this grade

≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 9 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
DROMETRIZOLE [USAN] | DTXCID207479 | NSC91885 | NCGC00166243-03 | UV-P | NCIOpen2_005624 | AS-12550 | DROMETRIZOLE [INN] | Ultraviolet Absorbent UV-P | Drometrizole | HMS2650F14 | MLS000713327 | NCGC00166243-02 | STK096143 | 2-(2H-1, 2, 3-Benzotriazol-2-yl)
Specifications & Purity
≥99%
Storage
Room temperature
Shipped In
Normal
Purity
≥99%
Names and Identifiers
Pubchem Sid488182347
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488182347
Canonical SmilesCC1=CC(=C(C=C1)O)N2N=C3C=CC=CC3=N2
IUPAC Name2-(benzotriazol-2-yl)-4-methylphenol
InChIKeyMCPKSFINULVDNX-UHFFFAOYSA-N
INCHI1S/C13H11N3O/c1-9-6-7-13(17)12(8-9)16-14-10-4-2-3-5-11(10)15-16/h2-8,17H,1H3
Isomeric SMILES CC1=CC(=C(C=C1)O)N2N=C3C=CC=CC3=N2
WGK Germany 1
RTECS GO6860000
Molecular Weight 225.25
Reaxy-Rn 615546
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=615546&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassAzoles
SubclassTriazoles
Intermediate Tree Nodes Phenyltriazoles
Direct ParentPhenyl-1,2,3-triazoles
Alternative Parents Benzotriazoles  Para cresols  Toluenes  1-hydroxy-2-unsubstituted benzenoids  Heteroaromatic compounds  Azacyclic compounds  Organopnictogen compounds  Organooxygen compounds  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Phenyl-1,2,3-triazole - Benzotriazole - P-cresol - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Toluene - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as phenyl-1,2,3-triazoles. These are organic compounds containing a 1,2,3-triazole substituted by a phenyl group.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
PTH1R Tclin Parathyroid hormone receptor (47172 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRCA1 Tchem Breast cancer type 1 susceptibility protein (15908 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NPC1 Tchem Niemann-Pick C1 protein (18985 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAB9A Tbio Ras-related protein Rab-9A (22488 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
microRNA 21 (64692 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Luciferin 4-monooxygenase (66902 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PYK Pyruvate kinase (6726 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

16 results found

Lot NumberCertificate TypeDateItem
H2209424Certificate of AnalysisMay 20, 2026 H157228
L2103162Certificate of AnalysisSep 09, 2025 H157228
L2103165Certificate of AnalysisSep 09, 2025 H157228
E2129204Certificate of AnalysisMar 04, 2025 H157228
B2518372Certificate of AnalysisJun 19, 2024 H157228
J2422494Certificate of AnalysisJun 18, 2024 H157228
A2306457Certificate of AnalysisDec 08, 2022 H157228
A2306488Certificate of AnalysisDec 08, 2022 H157228
A2306491Certificate of AnalysisDec 08, 2022 H157228
A2306495Certificate of AnalysisDec 08, 2022 H157228
A2306509Certificate of AnalysisDec 08, 2022 H157228
A2306512Certificate of AnalysisDec 08, 2022 H157228
A2306515Certificate of AnalysisDec 08, 2022 H157228
F2509020Certificate of AnalysisDec 08, 2022 H157228
J2528018Certificate of AnalysisDec 08, 2022 H157228
H2209419Certificate of AnalysisJun 15, 2022 H157228

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Chemical and Physical Properties
Melt Point(°C)129-133°C
Molecular Weight225.250 g/mol
XLogP34.300
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass225.09 Da
Monoisotopic Mass225.09 Da
Topological Polar Surface Area50.900 Ų
Heavy Atom Count17
Formal Charge0
Complexity259.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Weihong Li, Chongjia Lin, Gan Huang, Jun Hur, Baoling Huang, Shuhuai Yao.  (2022)  Selective Solar Harvesting Windows for Full-Spectrum Utilization.  Advanced Science,  (21): (2201738).  [PMID:35666069] [10.1002/advs.202201738]
2. Yaping Gan, Yan Zhu.  (2022)  Multi-Residue Analysis of Chemical Additives in Edible Vegetable Oils Using QuEChERS Extraction Method Followed by Supercritical Fluid Chromatography.  MOLECULES,  27  (5): (1681).  [PMID:35268782] [10.3390/molecules27051681]
3. Yuan Deng, Kai Li, Qingqing Guan, Tianding Hu, Liang He.  (2022)  Novel CNFs-based organic UV-adsorber intercalated ZnAl-LDHs composited films with superior photothermal stability and mechanical properties.  INDUSTRIAL CROPS AND PRODUCTS,      [PMID:] [10.1016/j.indcrop.2022.114555]
4. Xiaoyan Ouyang, Ruiyu Liang, Yuling Hu, Gongke Li, Changying Hu, Qisheng Zhong.  (2021)  Hollow tube covalent organic framework for syringe filter-based extraction of ultraviolet stabilizer in food contact materials.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:34537658] [10.1016/j.chroma.2021.462538]
5. Cheng Jie, Kong Xiaojian, Liu Shucheng, Che Dandan, Sun Zhiwei, Li Guoliang, Ping Meiling, Tang Jingpu, You Jinmao.  (2018)  Determination of Ultraviolet Filters in Domestic Wastewater by LC–MS Coupled with Polydopamine-Based Magnetic Solid-Phase Extraction and Isotope-Coded Derivatization.  CHROMATOGRAPHIA,  81  (12): (1673-1684).  [PMID:] [10.1007/s10337-018-3650-x]
6. Yuchen Wang, Qianyi Huang, Siqi Zhang, Shan Liu, Hengxiang Li, Xiaodong Wang, Yan Wang, Rui Hou, Xiangrong Xu.  (2025)  In Vitro metabolism of six representative organic UV stabilizers (OUVs) in marine fish liver microsomes: Kinetics, mechanisms and bioaccumulation evaluation.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:40220380] [10.1016/j.jhazmat.2025.138211]
7. Siru Chen, Kaixin Lin, Sai Liu, Chui Ting Kwok, Lin Liang, Ze Li, Shuangdui Wu, Ziai Liu, Chuyao Wang, Aiqiang Pan, Jianheng Chen, Tsz Chung Ho, Shauhrat S. Chopra, Yihao Zhu, Qingping Sun, Wei Li, Borong Lin, Chi Yan Tso.  (2025)  Bioinspired metafilms for all-weather energy harvesting: Adaptive thermal regulation and raindrop electricity generation.  Science Advances,  11  (21):   [PMID:40408477] [10.1126/sciadv.adu2895]
8. Zhenguo Wang, Huimin Zhou, Weiwei Yang, Xialin Hu, Daqiang Yin.  (2025)  Can phthalate esters be used as tracers for benzotriazole ultraviolet stabilizers in aquatic environments? A case study of the Huangpu River, Shanghai, China.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:40505272] [10.1016/j.ecoenv.2025.118503]
9. Ze-Pei Zhao, Shi-Ye Zhu, Ying-Huang Hu, Yu-Ke Wan, Shang-Jun Xu, Jie-Zhi Ma, Deng-Ni Lai, An-Wei Chen, Yuan Yang, Lin Luo, Lin-Ying Cao.  (2026)  Benzotriazole ultraviolet stabilizers impair trophoblast function at nanomolar concentrations via GPER signaling: implications for placental health.  CHEMICO-BIOLOGICAL INTERACTIONS,      [PMID:41865781] [10.1016/j.cbi.2026.112055]
Solution Calculators
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