AMBMP hydrochloride - ≥98%(HPLC) , CAS No.2095432-75-8

CAS: 2095432-75-8 Cat. No.: A287986 Molecular Weight: 386.84

GRADE & PURITY ≥98%(HPLC)

Synonyms

BML 284 | CID 11210285 | N4-(1,3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride | BML-284 HCL | BML-284 hydrochloride | Wnt agonist 1

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Product Describtion:
Wnt agonist 1 (BML-284 HCL, AMBMP HCL) is a cell permeable Wnt signaling pathway activator, which induces β-catenin- and TCF-dependent transcriptional activity with EC50 of 0.7 μM.

Specifications

Synonyms

BML 284 | CID 11210285 | N4-(1, 3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2, 4-pyrimidinediamine hydrochloride | BML-284 HCL | BML-284 hydrochloride | Wnt agonist 1

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer cells. Also decreases embr

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 504772987
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504772987
• Canonical Smiles: COC1=CC=CC(=C1)C2=CC(=NC(=N2)N)NCC3=CC4=C(C=C3)OCO4.Cl
• IUPAC Name: 4-N-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine;hydrochloride
• InChIKey: XZOFNDFDGVAIEH-UHFFFAOYSA-N
• INCHI: 1S/C19H18N4O3.ClH/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16;/h2-9H,10-11H2,1H3,(H3,20,21,22,23);1H
• Molecular Weight: 386.84
• Reaxy-Rn: 32391834
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32391834&ln=

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 38.68, Max Conc. mM: 100
• Molecular Weight: 386.800 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 386.115 Da
• Monoisotopic Mass: 386.115 Da
• Topological Polar Surface Area: 91.500 Ų
• Heavy Atom Count: 27
• Formal Charge: 0
• Complexity: 455.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3