10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 6 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Ammonium Glycyrrhizinate Ammonium Glycyrrhizinate (AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt) is a unique product from Licorice root with a very high sweetness. Ammonium glycyrrhizinate is a direct inhibitor of HMGB1 wi
In vitro
Ammonium glycyrrhizinate (AG) prepared from glycyrrhizin dramatically protects AGS cells from H(2)O(2)-induced damage as measured by the integrity of actin cytoskeleton. AG also inhibits FeSO(4)-induced reactive oxygen radicals in a dose-dependent manner, suggesting the role for AG as a free radical scavenger.
In vivo
Ammonium glycyrrhizinate (28 mg/kg) leads to changes in the activity of some enzymes in the brain, the development of parenchymatous dystrophy of the liver which changed to acidophilic necrosis attended with signs of regeneration in mice and rats model. Ammonium glycyrrhizinate-loaded nonionic surfactant vesicles (NSVs) decreases edema and nociceptive responses when compared with Ammonium glycyrrhizinate alone and empty NSVs in mice model. Ammonium glycyrrhizinate up-regulates interleukin-10 (IL-10) level and down-regulates the tumor neurosis factor-α (TNF-α) level and inhibits the cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE) activity in the lung tissue of mice. Ammonium glycyrrhizinate -loaded non-ionic surfactant vesicles shows no toxicity, good skin tolerability and are able to improve the drug anti-inflammatory activity in mice. Ammonium glycyrrhizinate significantly decreases triglyceride, cholesterol, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels in rats. Ammonium glycyrrhizinate increases high density lipoprotein (HDL) levels increased in rats.
Cell Data
cell lines：
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Powder Purity:
| Isomeric SMILES | C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)O)O)O)O)C)(C)C(=O)O.N |
|---|---|
| Molecular Weight | 839.96 |
| Reaxy-Rn | 30023600 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30023600&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| 1. Guanhua Li, Sheng Li. (2022) Resources recycle of traditional Chinese medicine (TCM) wastewater 2: The UF-FO-MD hybrid system and wetting prevention. DESALINATION, [PMID:] [10.1016/j.desal.2022.115968] |
| 2. Wenwei Zhong, Yingnan Zhao, Shunquan Chen, Jialun Zhong, LiWei Guo, Dongyang Zheng, Chun Xie, Chao Ji, Yi Guo, Guangxi Dong, Fengyuan Zhang, Alicia An, Shaoping Li, Sheng Li. (2021) Resources recycle of traditional Chinese medicine (TCM) wastewater 1: Effectiveness of the UF-MD hybrid system and MD process optimization. DESALINATION, [PMID:] [10.1016/j.desal.2021.114953] |
| 3. Yan Zhang, Zhaojun Wang, Weimin Zhou, Guoquan Min, Meidong Lang. (2013) Cationic poly(ɛ-caprolactone) surface functionalized mesoporous silica nanoparticles and their application in drug delivery. APPLIED SURFACE SCIENCE, [PMID:] [10.1016/j.apsusc.2013.03.168] |
| 4. Yan Zhang, Jianjing Liu, Yutong Fu, Ke Tan, Zhaoyang Ye, Meidong Lang. (2013) Self-assembly of polyion complex nanocarriers from ammonium glycyrrhizinate and monomethoxy poly(ethylene glycol)-b-poly(γ-amino-ε-caprolactone). Journal of Materials Chemistry B, 1 (11): (1614-1621). [PMID:32260724] [10.1039/C3TB00012E] |
| 5. Qianru Gao, Weiyi Tian, Huabing Yang, Haiming Hu, Junping Zheng, Xiaowei Yao, Baifei Hu, Hongtao Liu. (2023) Shen-Ling-Bai-Zhu-San alleviates the imbalance of intestinal homeostasis in dextran sodium sulfate-induced colitis mice by regulating gut microbiota and inhibiting the NLRP3 inflammasome activation. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:37704122] [10.1016/j.jep.2023.117136] |
| 6. Jiajia Jin, Jun chen, Xin Shou, Keqing Shi, Xingjie Zan, Yan Zu, Xiaoying Huang. (2023) MAG-encapsulated PLGA microspheres for Lipopolysaccharide-induced acute lung injury. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, [PMID:] [10.1016/j.jddst.2023.104632] |
