Andarine - Moligand™, 10mM in DMSO , Agonist of Androgen receptor, CAS No.401900-40-1, Agonist of Androgen receptor

CAS: 401900-40-1 Cat. No.: A407814 Molecular Weight: 441.36 Beilstein Registry Number: 9666695 EC Number: 803-892-7

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

GTx-007, S-4 | (S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Andarine Andarine (GTx-007, S-4) is a selective non-steroidal androgen receptor (AR) agonist with K i of 4 nM, tissue-selective for anabolic organs. Phase 3.
In vitro

Andarine stimulates AR-mediated transcription to 93% of that observed for 1 nM DHT at a concentration of 10 nM.

In vivo

Andarine exhibits potent and efficacious anabolic activity and results in dose-dependent stimulation of growth in prostate, seminal vesicles, and levator ani muscle with the ED50 of 0.43 mg/day, 0.55 mg/day, and 0.14 mg/day, respectively. Besides, Andarine shows no dose-dependent effect on castration-induced change in FSH, and partially suppresses LH production at dose rates of 0.5 mg/day or higher. In dogs administrated by intravenous doses of Andarine (0.1, 1, 3, and 10 mg/kg), the total body clearance (CL) ranged from 7.4 mL/min/kg to 3.1 mL/min/kg, volume of distribution at steady state (Vss) is 1.39 L/kg and half-life of Andarine is 229 minutes, respectively. In addition, oral bioavailability is 38%, 62% and 91% for the 10 mg/kg, 1 mg/kg and 0.1 mg/kg doses, respectively. Andarine demonstrates tissue-selective pharmacological activity and significantly decreased prostate weight to 79.4% at a concentration of 0.5 mg/day in intact rats.
Cell Data

cell lines：Ba/F3 cell lines

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

GTx-007, S-4 | (S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Andarine (GTx-007, S-4) is a selective non-steroidal androgen receptor (AR) agonist with K_i of 4 nM, tissue-selective for anabolic organs. Phase 3.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of Androgen receptor

Names and Identifiers

• Isomeric SMILES: CC(=O)NC1=CC=C(C=C1)OC[C@@](C)(C(=O)NC2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)O
• Molecular Weight: 441.36
• Beilstein: 9666695
• Reaxy-Rn: 25414523
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25414523&ln=

Associated Targets(Human)

AR Tclin Androgen receptor (2 Activities)

Discover Target: AR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)