Astragaloside IV - 10mM in DMSO , CAS No.84687-43-4

CAS: 84687-43-4 Cat. No.: A426209 Molecular Weight: 784.97

GRADE & PURITY 10mM in DMSO

Synonyms

Astragaloside IV|84687-43-4|Astragaloside A|Cyclosiversioside F|Astrasieversianin XIV|1J6XA9YCFV|CHEBI:65457|83207-58-3|(2R,3R,4S,5S,6R)-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-14-hydroxy-15-[(2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,1

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications

Synonyms

Astragaloside IV | 84687-43-4 | Astragaloside A | Cyclosiversioside F | Astrasieversianin XIV | 1J6XA9YCFV | CHEBI:65457 | 83207-58-3 | (2R, 3R, 4S, 5S, 6R)-2-[[(1S, 3R, 6S, 8R, 9S, 11S, 12S, 14S, 15R, 16R)-14-hydroxy-15-[(2R, 5S)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7, 7, 12, 1

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Anti-inflammatory.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: CC1(C(CCC23C1C(CC4C2(C3)CCC5(C4(CC(C5C6(CCC(O6)C(C)(C)O)C)O)C)C)OC7C(C(C(C(O7)CO)O)O)O)OC8C(C(C(CO8)O)O)O)C
• IUPAC Name: (2R,3R,4S,5S,6R)-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-14-hydroxy-15-[(2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethyl-6-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy-9-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• InChIKey: QMNWISYXSJWHRY-YLNUDOOFSA-N
• INCHI: 1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33-,34+,37+,38-,39+,40-,41+/m0/s1
• Isomeric SMILES: C[C@]12CC[C@@]34C[C@@]35CC[C@@H](C([C@@H]5[C@H](C[C@H]4[C@@]1(C[C@@H]([C@@H]2[C@]6(CC[C@H](O6)C(C)(C)O)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O)(C)C)O[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O
• WGK Germany: 3
• Molecular Weight: 784.97
• Reaxy-Rn: 57087797
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=57087797&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Steroids and steroid derivatives
      • Subclass Steroidal glycosides
        • Level5 Steroidal saponins
          • Level6 Cucurbitacin glycosides

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Steroids and steroid derivatives
• Subclass: Steroidal glycosides
• Intermediate Tree Nodes: Steroidal saponins
• Direct Parent: Cucurbitacin glycosides
• Alternative Parents: Triterpene saponins Triterpenoids Cycloartanols and derivatives 16-beta-hydroxysteroids O-glycosyl compounds Oxanes Monosaccharides Tetrahydrofurans Tertiary alcohols Secondary alcohols Cyclic alcohols and derivatives Acetals Polyols Dialkyl ethers Oxacyclic compounds Primary alcohols Hydrocarbon derivatives
• Molecular Framework: Aliphatic heteropolycyclic compounds
• Substituents: Cucurbitacin glycoside skeleton - Triterpene saponin - Triterpene glycoside - Cycloartanol-skeleton - 9b,19-cyclo-lanostane-skeleton - Cycloartane-skeleton - Triterpenoid - 16-hydroxysteroid - 16-beta-hydroxysteroid - Hydroxysteroid - Glycosyl compound - O-glycosyl compound - Oxane - Monosaccharide - Tetrahydrofuran - Tertiary alcohol - Cyclic alcohol - Secondary alcohol - Organoheterocyclic compound - Oxacycle - Acetal - Dialkyl ether - Ether - Polyol - Alcohol - Organic oxygen compound - Primary alcohol - Hydrocarbon derivative - Organooxygen compound - Aliphatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as cucurbitacin glycosides. These are polycyclic compounds containing a carbohydrate derivative glycosidically linked to a curcubitane nucleus.
• External Descriptors: triterpenoid saponin - pentacyclic triterpenoid

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HepG2 (196354 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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Hepatitis B virus (7925 Activities)

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Duck hepatitis B virus (235 Activities)

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Mechanisms of Action

Chemical and Physical Properties

• Melt Point(°C): 295-296°C
• Molecular Weight: 785.000 g/mol
• XLogP3: 1.300
• Hydrogen Bond Donor Count: 9
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 7
• Exact Mass: 784.461 Da
• Monoisotopic Mass: 784.461 Da
• Topological Polar Surface Area: 228.000 Ų
• Heavy Atom Count: 55
• Formal Charge: 0
• Complexity: 1460.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 21
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Chan-juan Chai, Yao Sun, Rui-fang Chi, Hui-yu Yang, Bin Yang, Bao Li.  (2023)  Astragaloside IV alleviates LPS-induced cardiomyocyte hypertrophy and collagen expression associated with CCL2-mediated activation of NF-κB signaling pathway.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,      [PMID:38091841] [10.1016/j.bbrc.2023.149367]

2. Xin Zhao, Jinlong Luo, Ying Huang, Lei Mu, Jueying Chen, Zhen Liang, Zhanhai Yin, Dake Chu, Yong Han, Baolin Guo.  (2023)  Injectable Antiswelling and High-Strength Bioactive Hydrogels with a Wet Adhesion and Rapid Gelling Process to Promote Sutureless Wound Closure and Scar-free Repair of Infectious Wounds.  ACS Nano,      [PMID:37862553] [10.1021/acsnano.3c08625]

3. Qing Xu, Dekun Li, Meixu Wan, Yanxin Zhang, Zhi Li, Aichun Ju.  (2023)  An Online CMC–LC/MS Method for Screening Angiogenesis Promoting Components in Yiqi Fumai Lyophilization Injection (YQFM).  Natural Product Communications,      [PMID:] [10.1177/1934578X231182209]

4. Tianshu Chu, Qingye Li, Chun Dai, Xiang Li, Xiang Kong, Yangming Fan, Hongyan Yin, Jianjun Ge.  (2022)  A novel Nanocellulose-Gelatin-AS-IV external stent resists EndMT by activating autophagy to prevent restenosis of grafts.  Bioactive Materials,      [PMID:36330163] [10.1016/j.bioactmat.2022.10.013]

5. Xiaoyu Zhu, Fangze Tao, Li Zhang, Yajie Yu, Yanchao Xu, Gang Yang, Zhifeng Wei, Yidong Cheng, Xuelai Yin, Xinyuan Zhang, Wu Wei, Anxi Wang.  (2022)  Astragaloside IV Protects Detrusor from Partial Bladder Outlet Obstruction-Induced Oxidative Stress by Activating Mitophagy through AMPK-ULK1 Pathway.  Oxidative Medicine and Cellular Longevity,      [PMID:35873803] [10.1155/2022/5757367]

6. Xiaowei Wang, Yufen Li, Ji Li, Yaxuan Gu, Lihong Sang, Dongkai Wang.  (2020)  NIR stimulus-responsive AstragalosideIV-Indocyanin green liposomes for chemo-photothermal therapy.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.jddst.2020.102257]

7. Dongyu Xie, Ping Zhou, Lin Liu, Wenjing Jiang, Haina Xie, Liang Zhang, Donghao Xie.  (2019)  Protective Effect of Astragaloside IV on Hepatic Injury Induced by Iron Overload.  Biomed Research International,      [PMID:31428632] [10.1155/2019/3103946]

8. Jiamao Lin, Lijun Fang, Hui Li, Zhenxiang Li, Linmao Lyu, Haiyong Wang, Jun Xiao.  (2019)  Astragaloside IV alleviates doxorubicin induced cardiomyopathy by inhibiting NADPH oxidase derived oxidative stress.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:31229536] [10.1016/j.ejphar.2019.172490]

9. Lu Jianrao, Yi Yang, Pan Ronghua, Zhang Chuanfu, Han Haiyan, Chen Jie, Liu Wenrui.  (2017)  Berberine protects HK-2 cells from hypoxia/reoxygenation induced apoptosis via inhibiting SPHK1 expression.  Journal of Natural Medicines,  72  (2): (390-398).  [PMID:29260413] [10.1007/s11418-017-1152-z]

10. Kong Chenfan, Sun Jianrong, Hu Xinzi, Li Guangzhi, Wu Song.  (2024)  A tumor targeted nano micelle carrying astragaloside IV for combination treatment of bladder cancer.  Scientific Reports,  14  (1): (1-14).  [PMID:39085255] [10.1038/s41598-024-66010-3]

11. Gao Jiaming, Guo Hao, Li Junmei, Zhan Min, You Yue, Xin Gaojie, Liu Zixin, Fan Xiaodi, Gao Qinghe, Liu Jianxun, Zhang Yehao, Fu Jianhua.  (2024)  Buyang Huanwu decoction ameliorates myocardial injury and attenuates platelet activation by regulating the PI3 kinase/Rap1/integrin α(IIb)β(3) pathway.  Chinese Medicine,  19  (1): (1-17).  [PMID:39160598] [10.1186/s13020-024-00976-0]

12. Fengyan Tang, Bo Zhao, Li Zhang, Faisal Raza, Hajra Zafar, Shao Zhong, Lin Li, Wenhua Zhu, Lingna Fang, Bing Lu, Liwen Shen, Ping Guo, Nengxing Yu, Quanmin Li.  (2024)  Co-treatment of Astragaloside IV with Vitamin D in Diabetic Peripheral Neuropathic Rats: Protective Effects and Potential Mechanisms.  Current Molecular Pharmacology,  17  (1): (e18761429267000).  [PMID:38254301] [10.2174/0118761429267000231004111024]

13. Song Wang, Xinnan Chang, Jing Li, Zuoqiao Shi, Guowen Li.  (2025)  Identification of chemical components and metabolites in rats after oral administration of Epimedium-Astragalus granule pair by liquid chromatography-high resolution mass spectrometry combined with diagnostic fragment ions and mass defect filtering.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:40014893] [10.1016/j.jpba.2025.116768]

14. Yong Jiang, Wenjun Ji, Ying Lu, Qin Wang, Linwei Chen.  (2025)  Integrating Plasma Metabolomics, Network Pharmacology, and Experimental Validation to Investigate the Action Mechanism of Qiangxin Lishui Prescription in Chronic Heart Failure.  BIOMEDICAL CHROMATOGRAPHY,  39  (2): (e6065).  [PMID:39748248] [10.1002/bmc.6065]

15. Wang Liwei, Zhang Lu, Yun Yang, Liang Tingting, Yan Chaoqun, Mao Zhuoya, Zhang Jingfang, Liu Baoshe, Zhang Jian, Liang Taigang.  (2024)  Protective effect of astragaloside IV against zinc oxide nanoparticles induced human neuroblastoma SH-SY5Y cell death: a focus on mitochondrial quality control.  MOLECULAR AND CELLULAR BIOCHEMISTRY,      [PMID:39630360] [10.1007/s11010-024-05172-0]

16. Zong-hui Xu, Man Li, Lin Liu, Shu-jing Wu, Ruo-an Wei, Mpofu Uphakeme Inobubele Sitholumusa, Xiao-ping Zhao, Jun-qiu Liu, Guo-yin Kai.  (2025)  Astragaloside IV alleviates LPS-induced acute lung injury by regulating receptor C5aR1 and macrophage pyroptosis.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:40618503] [10.1016/j.intimp.2025.115176]

17. Tianye Zheng, Xuelan Gan, Jianguo Luo, Zhongbo Shi, Yunfei Zhao, Yan Wang, Jun Chen, Chao Yu.  (2024)  Hyaluronic acid act as drug self-assembly chaperone and co-assembled with celalstrol for ameliorating non-alcoholic steatohepatitis.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39510469] [10.1016/j.ijbiomac.2024.137289]

18. You Xujun, Li Honghan, Li Qixin, Zhang Qing, Cao Yiguo, Fu Wei, Wang Bin.  (2025)  Astragaloside IV-PESV facilitates pyroptosis by enhancing palmitoylation of GSDMD protein mediated by ZDHHC1.  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY,      [PMID:40237800] [10.1007/s00210-025-04122-x]

19. Zhang Mingyang, Zhou Yijun, Yang Haiyan, Zheng Guangrong, Ren Li, Zhang Zhong, Lin Li, He Youqian, Wang Qi, Zou Jianzhong.  (2025)  Bacteria-based drug-loaded mesoporous silica nanoparticles for synergistic FUAS of breast cancer.  Cancer Nanotechnology,  16  (1): (1-19).  [PMID:] [10.1186/s12645-025-00327-0]

20. Yue Zhao, Yinlian Yao, Shilong Fan, Xin Shen, Jiahao Liu, Xingxing Chai, Xueqin Huang, Hua Jin, Zhikun Zhou.  (2025)  Intranasal delivery of platelet cell membrane-cloaked Astragaloside IV loaded biomimetic nanoparticles for enhanced therapeutics in acute lung injury mice.  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,      [PMID:40494449] [10.1016/j.ejpb.2025.114777]

21. Jing Ma, Lu Ding, Xiaoyu Zang, Yingying Yang, Wei Zhang, Xiangyan Li, Daqing Zhao, Zepeng Zhang, Zeyu Wang, Linhua Zhao, Xiaolin Tong.  (2025)  Qimai Feiluoping Decoction Inhibits EndMT to Alleviate Pulmonary Fibrosis by Reducing PI3K/AKT/mTOR Pathway-Mediated the Restoration of Autophagy.  Journal of Inflammation Research,      [PMID:40589610] [10.2147/JIR.S515286]

22. Yang Gang, Chen Ji-Yuan, Gong Chun-Ai, Wang Rong, Han Lu, Wang Jing, Chen Min-Yan, Yuan Yong-Fang.  (2025)  Astragaloside IV-loaded zeolitic imidazolate framework-8 based on supercritical fluid as anti-solvent technology to improve bioavailability and anti-tumor activity against non-small cell lung cancer.  Cancer Cell International,  25  (1): (1-21).  [PMID:41188833] [10.1186/s12935-025-04028-x]