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Camizestrant - ≥99% , Estrogen receptor alpha degrader, CAS No.2222844-89-3, Estrogen receptor alpha degrader

CAS: 2222844-89-3 Cat. No.: A414295 Molecular Weight: 476.51
COA
Camizestrant - ≥99% CAS No(2222844-89-3) by Aladdin Scientific
AVAILABLE TO ORDER
GRADE & PURITY ≥99%
Synonyms
AZD9833 | AZD-9833 | N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]pyridin-3-amine | N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Size
Status
Price
Qty
1mg
A414295-1mg
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5mg
A414295-5mg
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10mg
A414295-10mg
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$437.90

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25mg
A414295-25mg
3

$958.90

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50mg
A414295-50mg
2

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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Overview Specifications Product Properties Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews
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Why this grade

≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

AZD9833 is an orally available and selectiveestrogen receptor (ER)antagonist with antineoplastic activity.


Targets

ER


In vitro

AZD9833 is demonstrated to be a highly potent selective estrogen receptor degraders (SERD) that shows a pharmacological profile comparable to fulvestrant in its ability to degrade ERα in both MCF-7 and CAMA-1 cell lines.


In vivo

A stringent control of lipophilicity ensures that AZD9833 has favorable physicochemical and preclinical pharmacokinetic properties for oral administration. AZD9833 is potent in vivo activity in mouse xenograft models.


Cell Research(from reference)

Cell lines：MCF-7 cells 

Concentrations：100 nM 

Incubation Time：24 h 

Specifications

Synonyms
AZD9833 | AZD-9833 | N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S, 8R)-8-methyl-7-(2, 2, 2-trifluoroethyl)-3, 6, 8, 9-tetrahydropyrazolo[4, 3-f]isoquinolin-6-yl]pyridin-3-amine | N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6S, 8R)-8-methyl-7-(2, 2, 2-trifluoroethyl)-6, 7,
Specifications & Purity
≥99%
Biochemical and Physiological Mechanisms
AZD9833 is an orally available and selective estrogen receptor (ER) antagonist with antineoplastic activity.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
DEGRADER
Mechanism of action
Estrogen receptor alpha degrader
Purity
≥99%
Product Properties
ALogP4.2
Names and Identifiers
Canonical SmilesCC1CC2=C(C=CC3=C2C=NN3)C(N1CC(F)(F)F)C4=NC=C(C=C4)NC5CN(C5)CCCF
IUPAC NameN-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]pyridin-3-amine
InChIKeyWDHOIABIERMLGY-CMJOXMDJSA-N
INCHI1S/C24H28F4N6/c1-15-9-19-18(4-6-21-20(19)11-30-32-21)23(34(15)14-24(26,27)28)22-5-3-16(10-29-22)31-17-12-33(13-17)8-2-7-25/h3-6,10-11,15,17,23,31H,2,7-9,12-14H2,1H3,(H,30,32)/t15-,23+/m1/s1
Isomeric SMILES C[C@@H]1CC2=C(C=CC3=C2C=NN3)[C@H](N1CC(F)(F)F)C4=NC=C(C=C4)NC5CN(C5)CCCF
Molecular Weight 476.51
Reaxy-Rn 37989278
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37989278&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassPyridines and derivatives
SubclassBipyridines and oligopyridines
Intermediate Tree Nodes Not available
Direct ParentBipyridines and oligopyridines
Alternative Parents Tetrahydroisoquinolines  Indazoles  Secondary alkylarylamines  Aralkylamines  Aminopyridines and derivatives  Benzenoids  Pyrazoles  Heteroaromatic compounds  Trialkylamines  Azetidines  Azacyclic compounds  Organopnictogen compounds  Organofluorides  Hydrocarbon derivatives  Alkyl fluorides  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Bipyridine - Tetrahydroisoquinoline - Indazole - Benzopyrazole - Aralkylamine - Secondary aliphatic/aromatic amine - Aminopyridine - Benzenoid - Heteroaromatic compound - Pyrazole - Azole - Tertiary aliphatic amine - Tertiary amine - Azetidine - Azacycle - Secondary amine - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Organofluoride - Organohalogen compound - Amine - Alkyl halide - Alkyl fluoride - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as bipyridines and oligopyridines. These are organic compounds containing two pyridine rings linked to each other.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
ESR1 Tclin Estrogen receptor (7 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeDateItem
I2425102Certificate of AnalysisJul 16, 2024 A414295
I2425103Certificate of AnalysisJul 16, 2024 A414295
I2425104Certificate of AnalysisJul 16, 2024 A414295
I2425105Certificate of AnalysisJul 16, 2024 A414295
I2425107Certificate of AnalysisJul 16, 2024 A414295
I2425108Certificate of AnalysisJul 16, 2024 A414295
I2425110Certificate of AnalysisJul 16, 2024 A414295
I2425111Certificate of AnalysisJul 16, 2024 A414295
Chemical and Physical Properties
SolubilitySolubility：DMSO : 95 mg/mL；Ethanol : 95 mg/mL；Water : Insoluble
Molecular Weight476.500 g/mol
XLogP34.200
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass476.231 Da
Monoisotopic Mass476.231 Da
Topological Polar Surface Area60.100 Ų
Heavy Atom Count34
Formal Charge0
Complexity674.000
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Solution Calculators
Reviews

Customer Reviews

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