7-(Thiophene-2-acetamido)cephalosporanic acid sodium salt | Cephalothin sodium [USAN:USP] | Cephalotin sodium salt, Antibiotic for Culture Media Use Only | Cepovenin | NSC-756667 | Cefalotin sodium, European Pharmacopoeia (EP) Reference Standard | Cephalo
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Cephalothin sodium salt is a first generation cephem antibiotic with a wide range antibacterial activity. The compound is active against gram-positive and gram-negative bacteria, and has been tested in respiratory disease and neuromuscular junction studies. Cephalothin is a first-generation cephalosporin antibiotic used to study the mechanism of liposome encapsulated antibiotics,strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics,and for immunology studies in relation to antibiotics.It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.
Specifications
Synonyms
7-(Thiophene-2-acetamido)cephalosporanic acid sodium salt | Cephalothin sodium [USAN:USP] | Cephalotin sodium salt, Antibiotic for Culture Media Use Only | Cepovenin | NSC-756667 | Cefalotin sodium, European Pharmacopoeia (EP) Reference Standard | Cephalo
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Mode of Action: Inhibits cell wall synthesis.Antimicrobial spectrum: Gram-positive cocci.Mode of Resistance: Cephalosporinase production.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
This compound belongs to the class of organic compounds known as n-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid (or a derivative thereof) which bears an acyl group at its terminal nitrogen atom.
External Descriptors
organic sodium salt
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Shuqi Xing, Wei Xie, Guangli Hu, Chaocheng Luo, Hong Zhu, Laping He, Cuiqin Li, Xiao Wang, Xuefeng Zeng. (2024) The synthesis of cinnamyl acetate and deacetyl-7-aminocephalosporanic acid by a GDSL-type esterase and its substrate specificity analysis. ENZYME AND MICROBIAL TECHNOLOGY, [PMID:39471645][10.1016/j.enzmictec.2024.110532]
2.Hui Yang, Yunlong Wei, Xiufang Yan, Chao Nie, Zhenchun Sun, Likai Hao, Xiankun Su. (2022) High-Efficiency Utilization of Waste Tobacco Stems to Synthesize Novel Biomass-Based Carbon Dots for Precise Detection of Tetracycline Antibiotic Residues. Nanomaterials, 12 (18):(3241). [PMID:36145029][10.3390/nano12183241]
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