CH-223191 - Moligand™,10mM in DMSO , CAS No.301326-22-7
En stock
SKU
C408298
AhR Antagonists
Information
CH-223191 CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM.
In vitro
CH-223191 blocks TCDD-mediated nuclear translocation and DNA binding of AhR, and also causes the inhibition of TCDD-induced cytochrome P450 enzyme activity. In human glioblastoma cells, CH-223191downregulates the TGF-beta/Smad pathway, and reduces clonogenic survival and invasiveness. In SK-N-SH human-derived neuronal cells, CH223191 counteracts the TCDD-induced suppression of neuronal acetylcholinesterase expression. In endothelial cells, CH-223191 potentiates ICAM-1 expression and prevents RelB nuclear translocation.
In vivo
CH-223191 (10 mg/kg/day, p.o.) potently prevents TCDD-caused cytochrome P450 induction, liver toxicity, and wasting syndrome in mice.
Cell Data
cell lines：PAE
Concentrations：
Incubation Time：
Powder Purity:≥99%
Plus d’information
| CAS | 301326-22-7 |
|---|---|
| Concentration | 10mM in DMSO |
| Synonymes | 2-methyl-N-[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]pyrazole-3-carboxamide |
| Spécifications et pureté | Moligand™,10mM in DMSO |
| Conditions de stockage de stockage | Store at -80°C |
| Expédié en | Dry ice packs + Cold packs |
| Product Description | Information CH-223191 CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM. CH-223191 blocks TCDD-mediated nuclear translocation and DNA binding of AhR, and also causes the inhibition of TCDD-induced cytochrome P450 enzyme activity. In human glioblastoma cells, CH-223191downregulates the TGF-beta/Smad pathway, and reduces clonogenic survival and invasiveness. In SK-N-SH human-derived neuronal cells, CH223191 counteracts the TCDD-induced suppression of neuronal acetylcholinesterase expression. In endothelial cells, CH-223191 potentiates ICAM-1 expression and prevents RelB nuclear translocation. In vivo CH-223191 (10 mg/kg/day, p.o.) potently prevents TCDD-caused cytochrome P450 induction, liver toxicity, and wasting syndrome in mice. cell lines：PAE Concentrations： Incubation Time： Powder Purity:≥99% |
| Numéro CE | 683-682-8 |
| Formule moléculaire | C19H19N5O |
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