Chloramphenicol succinate sodium salt - ≥80%(HPLC) , Bacterial 70S ribosome inhibitor, CAS No.982-57-0, Bacterial 70S ribosome inhibitor

CAS: 982-57-0 Cat. No.: C463077 Molecular Weight: 445.19 EC Number: 213-568-1

GRADE & PURITY ≥80%(HPLC)

Synonyms

sodium 4-((2R,3R)-2-(2,2-dichloroacetamido)-3-hydroxy-3-(4-nitrophenyl)propoxy)-4-oxobutanoate | Protophenicol | CCRIS 6204 | CHLORAMPHENICOL SODIUM SUCCINATE [USP MONOGRAPH] | Chloramphenicol succinate sodium | LEVOMYCETIN-NALCEIN | sodium;4-[(2R,3R)-2-[

Storage

Room temperature

Overview

Description

Chemical structure: phenicoleChloramphenicol is often used for bacterial selection in molecular biology applications at 10-20 μg/mL and as a selection agent for transformed cells containing chloramphenicol reistance genes.

Preparation instructions

Stock solutions can be prepared directly in the vial at any recommended concentration. A solution at 50 mg/mL in ethanol yields a clear, very faint, yellow solution. Degradation of chloramphenicol in aqueous solution is catalyzed by general acids and bases. This rate of degradation is independent of the ionic strength and pH.

Specifications

Synonyms

sodium 4-((2R, 3R)-2-(2, 2-dichloroacetamido)-3-hydroxy-3-(4-nitrophenyl)propoxy)-4-oxobutanoate | Protophenicol | CCRIS 6204 | CHLORAMPHENICOL SODIUM SUCCINATE [USP MONOGRAPH] | Chloramphenicol succinate sodium | LEVOMYCETIN-NALCEIN | sodium;4-[(2R, 3R)-2-[

Specifications & Purity

≥80%(HPLC)

Storage

Room temperature

Action Type

INHIBITOR

Mechanism of action

Bacterial 70S ribosome inhibitor

Purity

≥80%(HPLC)

Names and Identifiers

• Canonical Smiles: C1=CC(=CC=C1C(C(COC(=O)CCC(=O)[O-])NC(=O)C(Cl)Cl)O)[N+](=O)[O-].[Na+]
• IUPAC Name: sodium;4-[(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propoxy]-4-oxobutanoate
• InChIKey: RPLOPBHEZLFENN-HTMVYDOJSA-M
• INCHI: 1S/C15H16Cl2N2O8.Na/c16-14(17)15(24)18-10(7-27-12(22)6-5-11(20)21)13(23)8-1-3-9(4-2-8)19(25)26;/h1-4,10,13-14,23H,5-7H2,(H,18,24)(H,20,21);/q;+1/p-1/t10-,13-;/m1./s1
• Isomeric SMILES: C1=CC(=CC=C1[C@H]([C@@H](COC(=O)CCC(=O)[O-])NC(=O)C(Cl)Cl)O)[N+](=O)[O-].[Na+]
• Molecular Weight: 445.19
• Reaxy-Rn: 4102380
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4102380&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Nitrobenzenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Nitrobenzenes
• Intermediate Tree Nodes: Not available
• Direct Parent: Nitrobenzenes
• Alternative Parents: Nitroaromatic compounds Fatty acid esters Dicarboxylic acids and derivatives Secondary carboxylic acid amides Secondary alcohols Carboxylic acid esters Carboxylic acid salts Propargyl-type 1,3-dipolar organic compounds Carboxylic acids Organic metal halides Organic oxoazanium compounds Organic zwitterions Hydrocarbon derivatives Organochlorides Organonitrogen compounds Aromatic alcohols Organopnictogen compounds Carbonyl compounds Organic oxides Alkyl chlorides Organic sodium salts
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Nitrobenzene - Nitroaromatic compound - Fatty acid ester - Dicarboxylic acid or derivatives - Fatty acyl - Carboxamide group - Carboxylic acid ester - Carboxylic acid salt - C-nitro compound - Organic nitro compound - Secondary alcohol - Secondary carboxylic acid amide - Carboxylic acid derivative - Carboxylic acid - Organic metal halide - Organic alkali metal salt - Organic oxoazanium - Allyl-type 1,3-dipolar organic compound - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organic oxygen compound - Organonitrogen compound - Organochloride - Carbonyl group - Organohalogen compound - Hydrocarbon derivative - Organic oxide - Alkyl halide - Alkyl chloride - Organopnictogen compound - Organooxygen compound - Organic sodium salt - Organic salt - Aromatic alcohol - Organic zwitterion - Organic nitrogen compound - Alcohol - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as nitrobenzenes. These are compounds containing a nitrobenzene moiety, which consists of a benzene ring with a carbon bearing a nitro group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: H2O: 50mg/mL
• Melt Point(°C): >42ºC
• Molecular Weight: 445.200 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 9
• Exact Mass: 444.01 Da
• Monoisotopic Mass: 444.01 Da
• Topological Polar Surface Area: 162.000 Ų
• Heavy Atom Count: 28
• Formal Charge: 0
• Complexity: 541.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Chang Liu, Diandian Deng, Di Xu, Kang Wu, Hong Yang, Kang Zhao, Jianguo Li, Anping Deng.  (2018)  Development of a monoclonal antibody based-ELISA for the detection of chloramphenicol in shrimp, feed and milk samples and validation by LC-MS/MS coupled with immunoaffinity clean-up.  Analytical Methods,  11  (4): (507-516).  [PMID:] [10.1039/C8AY02284D]