CHMFL-PI3KD-317 - Moligand™, 10 mM in DMSO , CAS No.2244992-76-3

CAS: 2244992-76-3 Cat. No.: C1494651 PubChem CID: 137333450

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC 50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC 50 , 62.6 nM), PI3Kβ (IC 50 , 284 nM), PI3Kγ (IC 50 , 202.7 nM), PIK3C2A (IC 50 , >10000 nM), PIK3C2B (IC 50 , 882.3 nM), VPS34 (IC 50 , 1801.7 nM), PI4KIIIA (IC 50 , 574.1 nM) and PI4KIIIB (IC 50 , 300.2 nM). CHMFL-PI3KD-317 inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells, with an EC 50 of 4.3 nM. CHMFL-PI3KD-317 has antiproliferative effects on cancer cells.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CC1=CC(=CC=C1)S(=O)(=O)NC2=C(N=CC(=C2)C3=C(N=C(S3)NC(=O)[C@H](C(C)C)N)C)Cl
• PubChem CID: 137333450
• MeSH Entry Terms: (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide;CHMFL-PI3KD-317